Alkylating Antineoplastic Agents

Antineoplastics

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Alkylating Antineoplastic Agents

Alkylating antineoplastic agents are cytotoxic APIs that form covalent bonds with DNA, leading to cross-linking, strand breaks, and inhibition of replication and transcription. This class includes nitrogen mustards, nitrosoureas, alkyl sulfonates, triazenes, and platinum-based drugs. They are effective against a wide range of hematologic malignancies and solid tumors such as breast cancer, ovarian cancer, sarcomas, and brain tumors. Their mechanism is cell cycle–nonspecific, making them particularly active against rapidly dividing cells. However, their strong cytotoxicity can result in bone marrow suppression, infertility, and secondary malignancies. Despite these risks, alkylating agents remain foundational drugs in many chemotherapeutic regimens due to their broad antitumor activity.

17-Oxo-5-Androsten-3Beta-Yl-N,n-Bis(2'-Chloroethyl)Carbamate CAS NO 2998-59-6

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CAS No.:2998-59-6

Grade:Pharmacy Grade

Content:99.90%

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Dacrene CAS NO 20070-61-5

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CAS No.:20070-61-5

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Content:99.90%

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1-(4-Chlorophenyl)-3-[Di(2-Chloroethyl)Amino]Prop-2-En-1-One CAS NO 20266-88-0

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CAS No.:20266-88-0

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Content:99.90%

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Hexahydro-2-[Bis(2-Chloroethyl)Amino]-1,3,2-Diazaphosphorine 2-Oxide CAS NO 20982-36-9

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CAS No.:20982-36-9

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Content:99.90%

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4-[3-[Bis(2-Chloroethyl)Amino]-4-Methylbenzoyl]Morpholine CAS NO 21447-39-2

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CAS No.:21447-39-2

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Content:99.90%

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3-[Bis(2-Chloroethyl)Amino]-4-Methyl-n-(2-Thiazolyl)Benzamide CAS NO 21447-40-5

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CAS No.:21447-40-5

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Content:99.90%

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3-(Bis(2-Chloroethyl)Amino)-n-Ethyl-p-Toluamide CAS NO 21447-85-8

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CAS No.:21447-85-8

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Content:99.90%

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1-Aziridinyl 3-[Bis(2-Chloroethyl)Amino]-4-Methylphenyl Ketone CAS NO 21447-86-9

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CAS No.:21447-86-9

Grade:Pharmacy Grade

Content:99.90%

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