Description

Melphalan Flufenamide CAS NO 380449-51-4 is a peptide-drug conjugate (PDC) and a novel, targeted alkylating agent. This compound is specifically engineered to leverage the overexpression of aminopeptidases in tumor cells, enabling selective intracellular release of its cytotoxic payload. It is primarily required by pharmaceutical research and development organizations, contract manufacturing organizations (CMOs), and academic institutions focused on developing next-generation oncology therapeutics, particularly for hematological malignancies and solid tumors.

Application

• Active Pharmaceutical Ingredient (API) for targeted cancer therapy development.
• Research Chemical for in vitro and in vivo studies on peptide-drug conjugate mechanisms and efficacy.
• Preclinical Candidate for investigating novel treatment modalities for multiple myeloma and other cancers.
• Reference Standard for analytical method development and quality control in pharmaceutical manufacturing.
• Bioconjugation Studies for exploring new linker technologies and targeted delivery systems.
• Mechanistic Studies focusing on aminopeptidase-mediated drug activation and resistance pathways.

Basic Information

Product Name	Melphalan Flufenamide
CAS No.	380449-51-4
Molecular Formula	C24H30F3N3O5
Molecular Weight	497.51 g/mol
Synonyms	L-Melphalan-p-fluorobenzylamide; Melflufen; J1; Pepaxto® (brand name); L-3-[4-[Bis(2-chloroethyl)amino]phenyl]-N-[(4-fluorophenyl)methyl]-L-alaninamide; (2S)-2-[[4-[bis(2-chloroethyl)amino]phenyl]methylamino]-N-[(4-fluorophenyl)methyl]propanamide
EINECS	Contact for details

Quality Control

Our Melphalan Flufenamide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all test results and confirming compliance with relevant specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity ≤0.5% Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.