Description

CarbaMic acid, N-[(2S)-1,1',2',3-tetrahydro-2'-oxo-1'-[[2-(triMethylsilyl)ethoxy]Methyl]spiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-, 1,1-diMethylethyl ester is a sophisticated, high-purity chemical intermediate designed for advanced pharmaceutical synthesis. This compound is critical for researchers and manufacturers requiring precise building blocks in complex molecular construction, particularly in the development of targeted therapeutics. Its primary value lies in its role as a key synthon for constructing spirocyclic and fused heterocyclic systems prevalent in modern drug discovery. This product is essential for pharmaceutical R&D laboratories and fine chemical producers focused on oncology, neurology, and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those with spirocyclic indole or pyrrolopyridine scaffolds.
• Drug Discovery Research: Used in medicinal chemistry for the design and construction of complex heterocyclic compounds targeting various disease pathways.
• Process Chemistry Development: Serves as a key starting material or advanced intermediate in the scale-up and optimization of synthetic routes for candidate drugs.
• Proteolysis-Targeting Chimera (PROTAC) Synthesis: Potential utility as a component in the linker or warhead sections of bifunctional degrader molecules due to its complex, functionalized structure.
• Chemical Biology Probe Development: Employed in creating specialized molecular tools for studying enzyme function and protein-protein interactions within biological systems.

Basic Information

Product Name	CarbaMic acid, N-[(2S)-1,1',2',3-tetrahydro-2'-oxo-1'-[[2-(triMethylsilyl)ethoxy]Methyl]spiro[2H-indene-2,3'-[3H]pyrrolo[2,3-b]pyridin]-5-yl]-, 1,1-diMethylethyl ester
CAS No.	957121-35-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	tert-Butyl N-[(2S)-2'-oxo-1'-({2-[(trimethylsilyl)oxy]ethyl}carbamoyl)-1',2',3,3'-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl]carbamate; (2S)-5-[(tert-Butoxycarbonyl)amino]-1'-({2-[(trimethylsilyl)oxy]ethyl}carbamoyl)-1',2',3,3'-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'-one; CAS 957121-35-6; SEM-protected spirocyclic pyrrolopyridine carbamate; Advanced pharmaceutical intermediate 957121-35-6; Boc-protected amino spiro[indene-pyrrolopyridinone] derivative.
EINECS	Contact for details

Quality Control

Our CarbaMic acid derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and spectroscopic identification (NMR, MS). While produced to exacting in-house standards, specifications can be aligned with client requirements for critical projects. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccant packs or storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.