Description

(E)-2-Methyl-2-butenoic acid (3aR,3aβ,6aR,7aα,7bα,8aα,8bβ,8cα)-decahydro-6β-hydroxy-6,8aα-dimethyl-3-methylene-2-oxo-4H-bisoxireno[1,8a:2,3]azuleno[4,5-b]furan-4α-yl ester is a high-purity, complex diterpenoid ester with a defined stereochemistry, making it a valuable advanced intermediate for specialized organic synthesis. Its intricate polycyclic structure is critical for research and development in the pharmaceutical sector, particularly for exploring novel bioactive compounds. This compound is essential for R&D chemists and process development scientists working on complex natural product derivatives, targeted therapeutics, and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel drug candidates, especially those with complex polycyclic frameworks.
• Natural Product Synthesis: Used in the research-scale total or semi-synthesis of complex diterpenoids and related natural products for biological activity studies.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop new therapeutic agents with targeted mechanisms of action.
• Process Chemistry Development: Acts as a reference standard or an intermediate for scaling up synthetic routes in fine chemical and API manufacturing.
• Academic & Institutional Research: Utilized in universities and research institutes for exploratory organic synthesis and methodological development.
• Biochemical Probe Development: Potential use in creating specialized molecular probes for studying biological pathways and enzyme interactions.

Basic Information

Product Name	(E)-2-Methyl-2-butenoic acid (3aR,3aβ,6aR,7aα,7bα,8aα,8bβ,8cα)-decahydro-6β-hydroxy-6,8aα-dimethyl-3-methylene-2-oxo-4H-bisoxireno[1,8a:2,3]azuleno[4,5-b]furan-4α-yl ester
CAS No.	99956-50-0
Molecular Formula	C₂₅H₃₂O₇
Molecular Weight	444.52 g/mol
Synonyms	Tiglic acid, (3aR,3aβ,6aR,7aα,7bα,8aα,8bβ,8cα)-decahydro-6β-hydroxy-6,8aα-dimethyl-3-methylene-2-oxo-4H-bisoxireno[1,8a:2,3]azuleno[4,5-b]furan-4α-yl ester; 4α-Tigloyloxy-2β,3β:15,16-diepoxy-7βH-kaur-16-en-15-one; 7β,20-Epoxykaur-16-en-15-one, 4α-(2-methyl-2-butenoate); Kaurene diterpenoid ester; 4α-Tigloyloxy-2β,3β:15,16-diepoxy-7βH-ent-kaur-16-en-15-one; Fuerstione analog; ent-Kaurane derivative ester
EINECS	Contact for details

Quality Control

Our (E)-2-Methyl-2-butenoic acid diterpenoid ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable for pharmaceutical intermediates, and specifications can be aligned with client requirements for advanced R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This compound may be light-sensitive and should be handled under inert atmosphere for long-term storage to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 97.0%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.