Description

2-(Hydroxymethyl)propenoic acid (3S,4'R)-3aβ,4,5,6,6aβ,7,8,9,9aβ,9bα-decahydro-4'-methyl-6,9-bismethylene-2-oxospiro[azuleno[4,5-b]furan-3(2H),2'-oxetan]-4β-yl ester is a high-purity, complex organic ester derivative designed for advanced chemical synthesis and research. This compound is valued for its unique spirocyclic and azulene-fused structural framework, which makes it a versatile chiral building block in the development of novel active pharmaceutical ingredients (APIs) and specialty fine chemicals. It is primarily targeted at pharmaceutical R&D laboratories, biotechnology companies, and advanced material science sectors requiring high-specificity intermediates.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of complex drug candidates, particularly in oncology and anti-inflammatory therapeutic areas.
• Organic Synthesis Research: Used as a specialized building block in academic and industrial research for constructing novel spirocyclic and polycyclic molecular architectures.
• Asymmetric Catalysis: Acts as a precursor or ligand in the development of new catalytic systems due to its defined stereochemistry and functional groups.
• Fine Chemical Production: Employed in the manufacture of high-value specialty chemicals, including flavors, fragrances, and advanced polymers with specific optical properties.
• Reference Standard: Supplied as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	2-(Hydroxymethyl)propenoic acid (3S,4'R)-3aβ,4,5,6,6aβ,7,8,9,9aβ,9bα-decahydro-4'-methyl-6,9-bismethylene-2-oxospiro[azuleno[4,5-b]furan-3(2H),2'-oxetan]-4β-yl ester
CAS No.	99305-08-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2-(Hydroxymethyl)acrylic Acid Spiro[azuleno[4,5-b]furan-3(2H),2'-oxetan] Ester; (3S,4'R)-Decahydro-4'-methyl-6,9-bismethylene-2-oxospiro[azuleno[4,5-b]furan-3(2H),2'-oxetan]-4β-yl 2-(Hydroxymethyl)propenoate; CAS 99305-08-5; Azulene-fused Spirocyclic Ester; Chiral Spirooxetane-Azulene Derivative; Propenoic Acid, 2-(hydroxymethyl)-, (3S,4'R)-3aβ,4,5,6,6aβ,7,8,9,9aβ,9bα-decahydro-4'-methyl-6,9-bismethylene-2-oxospiro[azuleno[4,5-b]furan-3(2H),2'-oxetan]-4β-yl ester
EINECS	Contact for details

Quality Control

Our production of this high-grade synthetic intermediate adheres to strict cGMP guidelines where applicable, ensuring batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC, chiral chromatography, NMR, and mass spectrometry to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support compliance with global regulatory frameworks such as REACH and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider inert gas purging or desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.