Description

Spiro[furan-2(5H),2'-[2H]furo[3,2-c]pyrrolo[1,2-a]azepin]-5-one,1'-ethyl-1',3'a,4',5',6',8',9',10',10'a,10'b-decahydro-4-methyl-8'-[(2R,4R)-tetrahydro-4-methyl-5-oxo-2-furanyl]-,(1'R,2S,3'aS,8'R,10'aR,10'bS)-rel-(-)- is a complex spirocyclic organic compound with a defined stereochemistry, serving as a high-value advanced pharmaceutical intermediate (API) or building block in synthetic organic chemistry. Its intricate fused-ring structure makes it a critical precursor for the development of novel, biologically active molecules. This compound is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of potential drug candidates, particularly for central nervous system (CNS) or anti-infective applications.
• Medicinal Chemistry Research: Used as a core scaffold or a sophisticated synthon for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Serves as a critical intermediate in scaling up synthetic routes from laboratory to pilot plant scale for new chemical entities (NCEs).
• Asymmetric Synthesis: Utilized in chiral synthesis due to its defined stereocenters, enabling the construction of enantiomerically pure targets.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for methodological studies in heterocyclic and spiro compound chemistry.

Basic Information

Item	Details
Product Name	Spiro[furan-2(5H),2'-[2H]furo[3,2-c]pyrrolo[1,2-a]azepin]-5-one,1'-ethyl-1',3'a,4',5',6',8',9',10',10'a,10'b-decahydro-4-methyl-8'-[(2R,4R)-tetrahydro-4-methyl-5-oxo-2-furanyl]-,(1'R,2S,3'aS,8'R,10'aR,10'bS)-rel-(-)-
CAS No.	69772-72-1
Molecular Formula	C24H31NO5
Molecular Weight	413.51 g/mol
Synonyms	rel-(-)-1'-Ethyl-1',3'a,4',5',6',8',9',10',10'a,10'b-decahydro-4-methyl-8'-[(2R,4R)-tetrahydro-4-methyl-5-oxo-2-furanyl]spiro[furan-2(5H),2'-[2H]furo[3,2-c]pyrrolo[1,2-a]azepin]-5-one; Compound 69772-72-1; Spirofuropyrroloazepinone derivative; Advanced Spirocyclic Intermediate; (1'R,2S,3'aS,8'R,10'aR,10'bS)-rel-(-)- isomer
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.