Description

6,7-Dimethylspiro[Chroman-2,4'-Piperidin]-4-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disorder research. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates targeting neurological pathways.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies in drug discovery programs.
• API Synthesis: Employed in the development and scale-up processes for new active pharmaceutical ingredients, particularly for CNS disorders.
• Biochemical Tool Compound: Utilized in pharmacological research as a reference standard or probe to study specific biological targets.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	6,7-Dimethylspiro[Chroman-2,4'-Piperidin]-4-One Hydrochloride
CAS No.	1216162-07-0
Molecular Formula	C15H20ClNO2 • HCl
Molecular Weight	313.24 g/mol (for hydrochloride salt)
Synonyms	6,7-Dimethylspiro[chroman-2,4'-piperidin]-4-one HCl; 4-Oxo-6,7-dimethylspiro[chroman-2,4'-piperidine] hydrochloride; Spiro[chroman-2,4'-piperidin]-4-one, 6,7-dimethyl-, hydrochloride; 1216162-07-0; 6,7-Dimethyl-4-oxospiro[chroman-2,4'-piperidine] hydrochloride
EINECS	Contact for details

Quality Control

Our 6,7-Dimethylspiro[Chroman-2,4'-Piperidin]-4-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.