Description

Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-8-Ol, 9-(1,1-Dimethylethyl)Dimethylsilyloxyoctahydro-, 3As-(3A.Alpha.,8.Alpha.,9.Beta.,9A.Beta.,9B.Alpha.)- is a complex, high-purity spirocyclic organic compound with a protected hydroxyl group, serving as a critical advanced intermediate in sophisticated organic synthesis. Its value lies in its unique stereochemistry and functional group protection, enabling precise construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block for the research and development of new therapeutic agents, particularly in complex molecule synthesis.
• Fine Chemical Synthesis: Used in the multi-step synthesis of specialty chemicals, agrochemicals, and other high-value organic compounds requiring specific stereochemical control.
• Academic & Industrial Research: Serves as a valuable reagent in methodological studies and for exploring new synthetic pathways in organic chemistry laboratories.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production for target molecules.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) ether group allows for selective reactions elsewhere on the molecule, a crucial strategy in complex synthesis.

Basic Information

Product Name	Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-8-Ol, 9-(1,1-Dimethylethyl)Dimethylsilyloxyoctahydro-, 3As-(3A.Alpha.,8.Alpha.,9.Beta.,9A.Beta.,9B.Alpha.)-
CAS No.	156206-13-2
Molecular Formula	C22H37NO4Si
Molecular Weight	407.62 g/mol
Synonyms	9-[(1,1-Dimethylethyl)dimethylsilyl]oxy-3a,4,5,6,7,8,9,9a-octahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-8-ol (3aR,8R,9S,9aR,9bS)-; (3aR,8R,9S,9aR,9bS)-9-[(tert-Butyldimethylsilyl)oxy]octahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-8-ol; TBDMS-protected spirocyclic indolizinol; Octahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-8-ol, 9-[(1,1-dimethylethyl)dimethylsilyl]oxy-, (3aR,8R,9S,9aR,9bS)-; CAS 156206-13-2
EINECS	Contact for details

Quality Control

Our Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-8-Ol intermediate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Products undergo rigorous analytical testing, including HPLC, NMR, and chiral analysis, to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.