Description

Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-8-Ol, 9-(1,1-Dimethylethyl)Dimethylsilyloxyoctahydro-, 3As-(3A.Alpha.,8.Beta.,9.Beta.,9A.Beta.,9B.Alpha.)- is a complex, high-purity spirocyclic organic compound featuring a protected hydroxyl group, making it a valuable advanced pharmaceutical intermediate or key synthon for sophisticated organic synthesis. Its intricate molecular architecture is designed to serve as a critical building block in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high stereochemical control. This compound is essential for research institutions and fine chemical manufacturers engaged in cutting-edge drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those with spirocyclic or fused polycyclic frameworks.
• Organic Synthesis Building Block: Used in advanced medicinal chemistry for constructing novel molecular scaffolds with potential biological activity.
• Asymmetric Synthesis: Its defined stereochemistry (3A.Alpha.,8.Beta.,9.Beta.,9A.Beta.,9B.Alpha.) makes it valuable for chiral synthesis where specific three-dimensional orientation is crucial for drug efficacy.
• Process Chemistry & Scale-Up: Employed in the development and optimization of synthetic routes for new chemical entities (NCEs) from laboratory to pilot plant scale.
• Academic & Industrial Research: A key material for investigating new synthetic methodologies and structure-activity relationships (SAR) in drug discovery programs.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) ether group allows for selective protection and deprotection strategies in complex molecule assembly.

Basic Information

Item	Details
Product Name	Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-8-Ol, 9-(1,1-Dimethylethyl)Dimethylsilyloxyoctahydro-, 3As-(3A.Alpha.,8.Beta.,9.Beta.,9A.Beta.,9B.Alpha.)-
CAS No.	156257-98-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	9-(tert-Butyldimethylsilyloxy)-3aα,8β,9β,9aβ,9bα-octahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-8-ol; (3aα,8β,9β,9aβ,9bα)-9-[(1,1-Dimethylethyl)dimethylsilyl]oxy-octahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-8-ol; TBDMS-protected Spirocyclic Indolizinol; Spirocyclic TBDMS Ether Intermediate; CAS 156257-98-6; Advanced Spirocyclic Synthon
EINECS	Contact for details

Quality Control

Our Spirocyclohexane-1,2-1,3Dioxino4,5,6-Hiindolizin-8-Ol derivative is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support compliance with cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, it is recommended to keep the material at 2-8°C under an inert atmosphere to maintain stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.