Description

(2R,6S,7S,9R)-2α-[(1S,4S)-4-(3-Hydroxyphenyl)-4-methoxy-1-methylbutyl]-3β,9,11,11-tetramethyl-8-oxo-1-oxaspiro[5.5]undec-4-ene-7-carboxylic acid (2R,3R)-tetrahydro-2-methyl-5-oxofuran-3-yl ester is a complex, high-purity organic compound with a defined stereochemistry, making it a valuable intermediate for advanced pharmaceutical synthesis. Its intricate spirocyclic and esterified structure is critical for research and development in creating novel therapeutic agents, particularly in specialized medicinal chemistry. This compound is essential for B2B clients in the pharmaceutical, biotechnology, and fine chemical industries who require precise, high-quality building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of complex drug candidates, particularly for central nervous system (CNS) or anti-inflammatory targets.
• Medicinal Chemistry Research: Used in R&D for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) under GMP conditions.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Asymmetric Synthesis: Utilized in advanced organic synthesis to introduce specific stereocenters and complex molecular frameworks.
• Fine Chemical Production: A precursor for the manufacture of other specialized, high-value fine chemicals and advanced intermediates.

Basic Information

Item	Details
Product Name	(2R,6S,7S,9R)-2α-[(1S,4S)-4-(3-Hydroxyphenyl)-4-methoxy-1-methylbutyl]-3β,9,11,11-tetramethyl-8-oxo-1-oxaspiro[5.5]undec-4-ene-7-carboxylic acid (2R,3R)-tetrahydro-2-methyl-5-oxofuran-3-yl ester
CAS No.	95069-54-8
Molecular Formula	C34H48O8
Molecular Weight	584.75 g/mol
Synonyms	2α-[(1S,4S)-4-(3-Hydroxyphenyl)-4-methoxy-1-methylbutyl]-3β,9,11,11-tetramethyl-8-oxo-1-oxaspiro[5.5]undec-4-ene-7-carboxylic acid (2R,3R)-tetrahydro-2-methyl-5-oxofuran-3-yl ester; Spiro[5.5]undec-4-ene-7-carboxylic acid derivative; (2R,3R)-Tetrahydro-2-methyl-5-oxofuran-3-yl ester; CAS 95069-54-8; Complex Spirocyclic Ester Intermediate; Pharmaceutical Building Block 95069-54-8.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical R&D and GMP applications. Every batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and MS to confirm identity, purity, and stereochemical integrity. We provide comprehensive Certificates of Analysis (COA) detailing all critical parameters, ensuring full traceability and compliance with your internal specifications and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.