Description

Methyl N-[3-[bis(2-chloroethyl)amino]-N-[N2-[N2-[3-[bis(2-chloroethyl)amino]-3-phenyl-L-alanyl]-L-arginyl]-L-lysyl]-3-phenyl-L-alanyl]-L-histidinate tetrahydrochloride is a sophisticated, multi-functional peptide derivative designed for advanced research and development. This compound is of significant interest for its potential as a targeted therapeutic agent, particularly in oncology research, due to its structural complexity and functional groups. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on developing novel drug conjugates and targeted delivery systems.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or active component in the synthesis of novel anti-cancer agents and targeted therapeutics.
• Bioconjugation & Drug Delivery: Used in the development of antibody-drug conjugates (ADCs) and other targeted drug delivery platforms due to its reactive chloroethylamino groups and peptide backbone.
• Biochemical Research: Employed as a tool compound in studies investigating cell signaling pathways, apoptosis induction, and mechanism-of-action studies for alkylating agents.
• Preclinical Studies: Utilized in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and toxicity profiles of new therapeutic candidates.
• Peptide Chemistry: Acts as a complex building block for the synthesis of specialized peptides with designed biological activity.

Basic Information

Item	Details
Product Name	Methyl N-[3-[bis(2-chloroethyl)amino]-N-[N2-[N2-[3-[bis(2-chloroethyl)amino]-3-phenyl-L-alanyl]-L-arginyl]-L-lysyl]-3-phenyl-L-alanyl]-L-histidinate tetrahydrochloride
CAS No.	84434-76-4
Molecular Formula	C52H78Cl8N14O7
Molecular Weight	1244.9 g/mol (for free base, contact for exact salt form weight)
Synonyms	Melphalan Flufenamide Impurity; L-Histidine, N-[N2-[N2-[3-[bis(2-chloroethyl)amino]-3-phenyl-L-alanyl]-L-arginyl]-L-lysyl]-3-[bis(2-chloroethyl)amino]-3-phenyl-L-alanyl]-, methyl ester, tetrahydrochloride; Peptide-drug conjugate intermediate; Targeted alkylating agent peptide; melflufen related compound; Phenylalanine mustard peptide derivative
EINECS	Contact for details

Quality Control

Every batch of methyl N-[3-[bis(2-chloroethyl)amino]-N-[N2-[N2-[3-[bis(2-chloroethyl)amino]-3-phenyl-L-alanyl]-L-arginyl]-L-lysyl]-3-phenyl-L-alanyl]-L-histidinate tetrahydrochloride is manufactured and analyzed under strict quality systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for research chemicals. Comprehensive analytical data, including HPLC purity, identity confirmation (MS, NMR), and impurity profiling, is documented. Certificates of Analysis (COA) are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.