Description

Chlorambucil Sodium Salt is the water-soluble sodium salt form of the nitrogen mustard alkylating agent Chlorambucil. This modification enhances its solubility for formulation in aqueous systems, making it a critical intermediate in pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the life sciences sector for the synthesis and study of chemotherapeutic agents. The compound's activity is derived from its ability to form covalent bonds with DNA, interfering with replication and transcription processes.

Application

• Pharmaceutical Intermediate: Key starting material for the synthesis of Chlorambucil and related alkylating agent APIs.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action, cytotoxicity, and DNA alkylation.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Preclinical Development: Employed in the formulation of injectable or other aqueous-based dosage forms for animal studies.
• Bioconjugation Studies: Utilized in research exploring antibody-drug conjugates (ADCs) and other targeted cancer therapies.

Basic Information

Product Name	Chlorambucil Sodium Salt
CAS No.	1030-06-4
Molecular Formula	C14H19Cl2NNaO2
Molecular Weight	327.20 g/mol
Synonyms	4-[Bis(2-chloroethyl)amino]benzenebutanoic Acid Sodium Salt; Leukeran Sodium Salt; Chloraminophene Sodium Salt; NSC-75722; CB-1348 Sodium Salt; p-[N,N-Bis(2-chloroethyl)amino]phenylbutyric Acid Sodium Salt
EINECS	213-860-5

Quality Control

Our Chlorambucil Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting specifications suitable for research and development purposes. A detailed Certificate of Analysis (COA) providing results for assay, related substances, residual solvents, and other critical parameters is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.