Description

Melphalan is a bifunctional alkylating agent belonging to the nitrogen mustard class of chemotherapeutic drugs. Its primary value lies in its potent antineoplastic activity, which is critical for disrupting DNA replication and transcription in rapidly dividing cells. This compound is essential for pharmaceutical manufacturers and research institutions developing treatments for specific cancers, including multiple myeloma and ovarian carcinoma. We supply high-purity Melphalan CAS NO 148-82-3 to support global therapeutic and advanced research applications.

Application

• Oncological Pharmaceutical Manufacturing: As the active pharmaceutical ingredient (API) in chemotherapy formulations for treating multiple myeloma and ovarian cancer.
• Clinical Research & Drug Development: Used in preclinical and clinical studies to investigate new cancer treatment protocols and combination therapies.
• Reference Standard & Analytical Testing: Serves as a high-purity standard for quality control (QC) and analytical method development in pharmaceutical laboratories.
• Biomedical Research: Utilized in *in vitro* and *in vivo* studies to understand mechanisms of alkylating agent activity, DNA damage, and cellular apoptosis.
• Specialized Compounding: For the preparation of specific, patient-tailored chemotherapeutic regimens in specialized clinical settings.

Basic Information

Product Name	Melphalan
CAS No.	148-82-3
Molecular Formula	C13H18Cl2N2O2
Molecular Weight	305.20 g/mol
Synonyms	L-Phenylalanine mustard; L-Sarcolysin; Alkeran; CB-3025; NSC-8806; 4-[Bis(2-chloroethyl)amino]-L-phenylalanine; (2S)-2-Amino-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoic acid
EINECS	205-725-8

Quality Control

Our Melphalan is manufactured and tested under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical active ingredients. Quality assurance includes comprehensive analytical testing for identity, purity, and impurities, referencing pharmacopeial standards where applicable. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. Due to its light-sensitive nature, handling and storage must strictly avoid all light exposure to maintain stability and potency. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	[α]20/D: Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.