Description

(E)-2-Methyl-2-butenoic acid [(3aS,6R)-2,3,3a,4,5,6,6aβ,7,9aβ,9bα-decahydro-5β,7α-dihydroxy-9-methyl-3-methylene-2-oxospiro[azuleno[4,5-b]furan-6,2'-oxiran]-4α-yl] ester is a high-purity, complex organic ester derivative with a specific stereochemical configuration. This compound is valued for its role as a key synthetic intermediate or reference standard in advanced pharmaceutical research and development. It is primarily targeted at R&D chemists and process development scientists working in the pharmaceutical, agrochemical, and fine chemical sectors who require structurally defined, high-quality building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for complex natural product derivatives or steroidal frameworks.
• Chemical Reference Standard: Used as a high-purity analytical standard for method development, validation, and quality control in laboratories to ensure product identity and purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore new therapeutic candidates.
• Process Chemistry Development: Acts as a starting material or intermediate in scaling up synthetic routes for potential drug candidates under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Synthesis: Potential use as an intermediate in the development of advanced, biologically active compounds for crop protection.
• Academic & Institutional Research: Utilized in universities and research institutes for studies in organic synthesis, catalysis, and the chemistry of complex molecular architectures.

Basic Information

Item	Details
Product Name	(E)-2-Methyl-2-butenoic acid [(3aS,6R)-2,3,3a,4,5,6,6aβ,7,9aβ,9bα-decahydro-5β,7α-dihydroxy-9-methyl-3-methylene-2-oxospiro[azuleno[4,5-b]furan-6,2'-oxiran]-4α-yl] ester
CAS No.	76461-22-8
Molecular Formula	C21H26O6
Molecular Weight	374.43 g/mol
Synonyms	2-Methylcrotonic acid (3aS,6R)-2,3,3a,4,5,6,6aβ,7,9aβ,9bα-decahydro-5β,7α-dihydroxy-9-methyl-3-methylene-2-oxospiro[azuleno[4,5-b]furan-6,2'-oxiran]-4α-yl ester; Tiglic acid derivative of a decahydrospiroazulenofuran; (E)-2-Methylbut-2-enoic acid ester; CAS 76461-22-8; Complex spiroazulenofuran ester; Tiglate ester of a polycyclic diol epoxide.
EINECS	Contact for details

Quality Control

Our (E)-2-Methyl-2-butenoic acid ester is produced and handled under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and chiral analysis to verify stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure full traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.