Description

(2R,4S)-4-[(2S)-2,5-Dihydro-2-methyl-5-oxofuran-2-yl]-3'β-(3-furyl)-3,4,4',5,5',5'aα-hexahydro-5,5-dimethylspiro[furan-2,8'-[1H,3H-3aβ,9bβ]methanofuro[3,4-f][1,2]benzodioxin]-1'-one is a complex, high-purity organic compound characterized by its intricate spirocyclic and fused ring structure. This compound is of significant interest in advanced pharmaceutical research and development, particularly as a sophisticated synthetic intermediate or a potential pharmacophore. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used as a key scaffold or precursor for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry Development: Employed in the optimization and scale-up of synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Academic Research: Utilized in universities and research institutes for studies in organic synthesis methodology, asymmetric catalysis, and the construction of complex molecular architectures.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development, quality control, and regulatory submissions.

Basic Information

Item	Details
Product Name	(2R,4S)-4-[(2S)-2,5-Dihydro-2-methyl-5-oxofuran-2-yl]-3'β-(3-furyl)-3,4,4',5,5',5'aα-hexahydro-5,5-dimethylspiro[furan-2,8'-[1H,3H-3aβ,9bβ]methanofuro[3,4-f][1,2]benzodioxin]-1'-one
CAS No.	73536-98-8
Molecular Formula	C27H28O8
Molecular Weight	480.51 g/mol
Synonyms	Methanofuro[3,4-f][1,2]benzodioxin derivative; Spiro[furan-2,8'-[1H,3H-3aβ,9bβ]methanofuro[3,4-f][1,2]benzodioxin]-1'-one; CAS 73536-98-8; (2R,4S,5'aα)-Isomer; Complex Furanobenzodioxin Spiro Compound; Advanced Pharmaceutical Intermediate 73536-98-8
EINECS	Contact for details

Quality Control

Our (2R,4S)-4-[(2S)-2,5-Dihydro-2-methyl-5-oxofuran-2-yl]-3'β-(3-furyl)-3,4,4',5,5',5'aα-hexahydro-5,5-dimethylspiro[furan-2,8'-[1H,3H-3aβ,9bβ]methanofuro[3,4-f][1,2]benzodioxin]-1'-one is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing specifications such as assay (HPLC), chiral purity, and related substances. Our quality commitment supports compliance with research and cGMP standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storage at 2-8°C. The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.