Description

6-Fluoro-8-Methyl-3,4-Dihydro-2H-1-Benzopyran-4-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzopyran scaffold with fluorine and amine functional groups. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and cardiovascular research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, especially in neurological and cardiovascular therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its fluorinated benzopyran core.
• API Synthesis: Serves as a crucial precursor in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Agrochemical Development: Potential application as an intermediate in the synthesis of new generation pesticides and herbicides.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying biological pathways and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	6-Fluoro-8-Methyl-3,4-Dihydro-2H-1-Benzopyran-4-Amine
CAS No.	1273650-72-8
Molecular Formula	C10H12FNO
Molecular Weight	181.21 g/mol
Synonyms	4-Amino-6-fluoro-8-methyl-3,4-dihydro-2H-1-benzopyran; 6-Fluoro-8-methyl-3,4-dihydro-2H-chromen-4-amine; 2H-1-Benzopyran-4-amine, 6-fluoro-3,4-dihydro-8-methyl-; 1273650-72-8; 6-Fluoro-8-methylchroman-4-amine; 4-Amino-6-fluoro-8-methylchroman
EINECS	Contact for details

Quality Control

Our 6-Fluoro-8-Methyl-3,4-Dihydro-2H-1-Benzopyran-4-Amine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system is designed to support cGMP (current Good Manufacturing Practice) standards for advanced intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.