Description

Propanoic acid, 2,2-dimethyl-, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,12,21-tetrahydroxy-17-(1R)-1-hydroxyethyl-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-en- is a complex, high-purity macrolide compound with a defined stereochemistry. This compound is of significant interest for advanced pharmaceutical research and development, particularly in the discovery of novel therapeutic agents. It is primarily sought by biotech and pharmaceutical companies engaged in the synthesis of specialized active pharmaceutical ingredients (APIs) and reference standards.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex macrolide-based active pharmaceutical ingredients (APIs).
• Research & Development: Used as a reference standard or starting material in medicinal chemistry programs for structure-activity relationship (SAR) studies.
• Biochemical Research: Potential application as a tool compound in pharmacological assays to study specific biological pathways or enzyme inhibition.
• Process Development: Employed in the development and optimization of scalable synthetic routes within process chemistry departments.
• Custom Synthesis: Acts as a precursor for the custom synthesis of labeled compounds (e.g., deuterated, C13) for analytical and metabolic studies.

Basic Information

Item	Details
Product Name	Propanoic acid, 2,2-dimethyl-, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,12,21-tetrahydroxy-17-(1R)-1-hydroxyethyl-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-en-
CAS No.	136448-57-2
Molecular Formula	C41H62O16
Molecular Weight	810.91 g/mol
Synonyms	Lonomycin A; Lonomycin; (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-1,11,12,21-Tetrahydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis[(2-methoxy-2-oxoethylidene)]-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-2-one; 2,2-Dimethylpropanoic acid ionomycin complex; Ionomycin (polyether antibiotic)
EINECS	Contact for details

Quality Control

Our Lonomycin A is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from tests including HPLC purity, chiral purity, NMR, and mass spectrometry confirmation. We support cGMP-compliant sourcing for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+Na]+
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% (by Chiral HPLC)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.