Description

2-(4-Methyl-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, also known as 4-Methyl-2-thienylboronic acid pinacol ester, is a high-purity organoboron building block essential for modern synthetic chemistry. This compound is a critical reagent for Suzuki-Miyaura cross-coupling reactions, enabling the efficient formation of carbon-carbon bonds. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors to synthesize complex molecules and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing thiophene heterocycles.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific thienyl motifs.
• Material Science: Enables the creation of organic electronic materials, such as conductive polymers, OLED (Organic Light-Emitting Diode) components, and semiconductors.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for constructing complex molecular architectures via palladium-catalyzed cross-coupling.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty and performance chemicals.

Basic Information

Product Name	2-(4-Methyl-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS No.	635305-48-5
Molecular Formula	C15H23BO2S
Molecular Weight	278.22 g/mol
Synonyms	4-Methyl-2-thienylboronic acid pinacol ester; 4-Methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene; 2-(4-Methylthiophen-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Methylthiophene-2-boronic acid pinacol ester; (4-Methyl-2-thienyl)boronic acid pinacol ester; 4-Methyl-2-thienylboronate pinacol ester; 2-(4-Methyl-2-thienyl)-1,3,2-dioxaborolane, 4,4,5,5-tetramethyl-
EINECS	Contact for details

Quality Control

Our 2-(4-Methyl-2-thienyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. We provide comprehensive analytical data, including NMR (1H, 13C, 11B) and HPLC analysis. Certificates of Analysis (COA) detailing purity and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.