Description

4,6-Methano-1,3,2-Benzodioxaborole-2-Methamine,Ar-(3-Bromopropyl)Boronic Acid (1S,2S,3R,5S)-(+)-2,3-Pinanediol Ester is a sophisticated chiral boronic ester derivative, serving as a critical advanced synthetic intermediate in modern organic chemistry. Its value lies in the stereochemical control and functional group versatility it provides, enabling the construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require high-purity, enantiomerically pure building blocks for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a protected, air-stable boronic acid equivalent for forming carbon-carbon bonds under mild conditions.
• Asymmetric Synthesis: Utilized in the preparation of enantiomerically enriched compounds for medicinal chemistry and catalysis research.
• Agrochemical Research: Serves as a building block for developing novel, chiral pesticides and herbicides with improved efficacy and selectivity.
• Material Science: Potential intermediate in the synthesis of organic electronic materials and liquid crystals where specific stereochemistry is required.
• Academic & R&D Laboratories: Used in methodological development and complex natural product synthesis.

Basic Information

Product Name	4,6-Methano-1,3,2-Benzodioxaborole-2-Methamine,Ar-(3-Bromopropyl)Boronic Acid (1S,2S,3R,5S)-(+)-2,3-Pinanediol Ester
CAS No.	131100-00-0
Molecular Formula	C₁₇H₂₃BBrNO₂
Molecular Weight	364.09 g/mol
Synonyms	(1S,2S,3R,5S)-(-)-Pinanediol [3-(Bromomethyl)phenyl]boronate; (3-Bromomethyl)phenylboronic acid pinanediol ester; (3-Bromobenzyl)boronic acid pinanediol ester; Ar-(3-Bromopropyl)boronic acid (+)-pinanediol ester; (1S,2S,3R,5S)-Pinanediol 3-(Bromomethyl)benzeneboronate; B-(3-(Bromomethyl)phenyl)boronic acid pinanediol ester; 3-Bromobenzylboronic acid pinanediol ester
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical characterization, including Chiral HPLC, ¹H/¹³C NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, chiral excess, and impurity profile is provided with every shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) when possible to maintain stability and purity. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.