Description

(3aS,4R,6E,10S,11aR)-2,3,3a,4,5,8,9,10,11,11a-Decahydro-10-hydroxymethyl-3-methylene-4-(2-methyl-1-oxopropoxy)-2-oxocyclodeca[b]furan-6-carboxylic acid methyl ester is a complex, high-purity synthetic intermediate of significant interest in advanced organic synthesis. Its intricate stereochemistry and functional groups make it a valuable chiral building block for the development of novel pharmacologically active compounds. This product is essential for research and development chemists in the pharmaceutical and biotechnology sectors, particularly those working on new drug candidates and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of potential active pharmaceutical ingredients (APIs), especially for complex macrocyclic or polycyclic structures.
• Medicinal Chemistry Research: Used as a sophisticated scaffold or building block for constructing compound libraries in drug discovery programs targeting new therapeutic areas.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material production.
• Natural Product Synthesis: Employed in the total or semi-synthesis of complex natural products and their derivatives for biological evaluation.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study biological pathways and enzyme functions.

Basic Information

Product Name	(3aS,4R,6E,10S,11aR)-2,3,3a,4,5,8,9,10,11,11a-Decahydro-10-hydroxymethyl-3-methylene-4-(2-methyl-1-oxopropoxy)-2-oxocyclodeca[b]furan-6-carboxylic acid methyl ester
CAS No.	67927-54-2
Molecular Formula	C₂₁H₂₈O₇
Molecular Weight	392.45 g/mol
Synonyms	Methyl (3aS,4R,6E,10S,11aR)-10-(hydroxymethyl)-3-methylene-4-[(2-methylpropanoyl)oxy]-2-oxo-3a,4,5,8,9,10,11,11a-octahydrocyclodeca[b]furan-6-carboxylate; 10-Hydroxymethyl-3-methylene-4-(2-methyl-1-oxopropoxy)-2-oxocyclodeca[b]furan-6-carboxylic acid methyl ester (stereoisomer); A complex macrocyclic furanone ester intermediate.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and controlled under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical research and development work. Certificates of Analysis (COA) detailing specifications such as chiral purity, chemical purity (by HPLC), and residual solvents are available for each lot. Our quality commitment supports compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storing under an inert atmosphere at lower temperatures (e.g., -20°C) to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.