Description

(3S,3aR,4R,4'aβ,7'α,7aR,9'aα)-3,3a,5,5',6,6',7,7',7a,8'-Decahydro-3,5'α-dihydroxy-7a-methyl-8'-methylenespiro[isobenzofuran-4(1H),4'(3'H)-[1H-7,9a]methanocyclohepta[c]pyran]-1',9'(4'aH)-dione is a complex, high-purity diterpenoid compound with a unique spirocyclic structure. This compound matters as a critical advanced pharmaceutical intermediate and a valuable scaffold for medicinal chemistry research, enabling the synthesis of novel bioactive molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex natural product derivatives and novel drug candidates.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis.
• Process Chemistry Development: Serves as a model compound for optimizing stereoselective synthesis and purification protocols.
• Reference Standard: High-purity material for analytical method development, validation, and quality control in API manufacturing.
• Academic Research: Investigated for its biological activity and as a subject in total synthesis projects.

Basic Information

Product Name	(3S,3aR,4R,4'aβ,7'α,7aR,9'aα)-3,3a,5,5',6,6',7,7',7a,8'-Decahydro-3,5'α-dihydroxy-7a-methyl-8'-methylenespiro[isobenzofuran-4(1H),4'(3'H)-[1H-7,9a]methanocyclohepta[c]pyran]-1',9'(4'aH)-dione
CAS No.	66548-00-3
Molecular Formula	C20H24O6
Molecular Weight	360.40 g/mol
Synonyms	7a-Methyl-8'-methylenespiro[isobenzofuran-4(1H),4'(3'H)-[1H-7,9a]methanocyclohepta[c]pyran]-1',9'(4'aH)-dione, 3,3a,5,5',6,6',7,7',7a,8'-decahydro-3,5'α-dihydroxy-, (3S,3aR,4R,4'aβ,7'α,7aR,9'aα)-; Spirocyclic Diterpenoid Dione; NSC 339586; A derivative of Steviol or Isosteviol.
EINECS	Contact for details

Quality Control

Our (3S,3aR,4R,4'aβ,7'α,7aR,9'aα)-3,3a,5,5',6,6',7,7',7a,8'-Decahydro-3,5'α-dihydroxy-7a-methyl-8'-methylenespiro[isobenzofuran-4(1H),4'(3'H)-[1H-7,9a]methanocyclohepta[c]pyran]-1',9'(4'aH)-dione is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral methods for stereochemical confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.