Description

(1S,2R)-10'β-Acetoxy-3',4',4'b,5',6',7',8',8'aβ,9',10'-decahydro-3'β,9'α-dihydroxy-2,4'bα-dimethyl-7',8'-bis(methylene)spiro[cyclopropane-1,2'(1'H)-phenanthrene]-1',4'-dione is a complex, high-purity diterpenoid derivative with a unique spirocyclic structure. This compound is valued as a critical advanced pharmaceutical intermediate for the research and synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing innovative drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel diterpenoid-based drug candidates, particularly in oncology and anti-inflammatory research.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical testing.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the exploration of new bioactive molecules.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of complex natural product derivatives.
• Academic Research: Utilized in university and institutional labs for studying diterpenoid chemistry, biosynthesis, and total synthesis projects.

Basic Information

Product Name	(1S,2R)-10'β-Acetoxy-3',4',4'b,5',6',7',8',8'aβ,9',10'-decahydro-3'β,9'α-dihydroxy-2,4'bα-dimethyl-7',8'-bis(methylene)spiro[cyclopropane-1,2'(1'H)-phenanthrene]-1',4'-dione
CAS No.	66451-12-5
Molecular Formula	C24H30O6
Molecular Weight	414.50 g/mol
Synonyms	10'-Acetoxy-3',9'-dihydroxy-2,4'bα-dimethyl-7',8'-bis(methylene)spiro[cyclopropane-1,2'(1'H)-phenanthrene]-1',4'-dione; (1S,2R)-10'-Acetoxy-3',9'-dihydroxy-2,4'bα-dimethyl-7',8'-bis(methylene)spiro[cyclopropane-1,2'(1'H)-phenanthrene]-1',4'-dione; Spirocyclopropanephenanthrenedione derivative; Diterpenoid spiroketal intermediate; CAS 66451-12-5
EINECS	Contact for details

Quality Control

Our production of (1S,2R)-10'β-Acetoxy-3',4',4'b,5',6',7',8',8'aβ,9',10'-decahydro-3'β,9'α-dihydroxy-2,4'bα-dimethyl-7',8'-bis(methylene)spiro[cyclopropane-1,2'(1'H)-phenanthrene]-1',4'-dione adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC purity analysis, structural confirmation (NMR, MS), and impurity profiling to ensure consistency and reliability for research applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.