Description

(E)-2-Methyl-2-butenoic acid [(1aR,2S,3R,4E,7R,7aR,8S,10aS,10bR)-1a,2,3,6,7,7a,8,9,10a,10b-decahydro-2,3-dihydroxy-1a,5,8-trimethyl-9-oxooxireno[9,10]cyclodeca[1,2-b]furan-7-yl] ester is a complex, high-purity chemical intermediate characterized by its specific stereochemistry and functional groups. This compound matters as a critical building block for advanced pharmaceutical synthesis and specialized organic research, where precise molecular architecture is paramount. It is needed by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and fine chemical sectors for developing novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key synthon for the research and development of novel therapeutic agents, particularly in oncology and anti-infective drug discovery.
• Advanced Organic Synthesis: Serves as a sophisticated chiral building block for constructing complex polycyclic frameworks in academic and industrial research.
• Agrochemical Research: Used in the synthesis of experimental pesticides and herbicides with specific bioactive profiles.
• Natural Product Analog Synthesis: Enables the semi-synthesis and structural modification of complex natural products for structure-activity relationship (SAR) studies.
• Biochemical Probe Development: Utilized in creating specialized molecular probes for studying enzyme mechanisms and biological pathways.
• Material Science Research: Potential precursor for specialized polymers or liquid crystals requiring specific chiral centers.

Basic Information

Product Name	(E)-2-Methyl-2-butenoic acid [(1aR,2S,3R,4E,7R,7aR,8S,10aS,10bR)-1a,2,3,6,7,7a,8,9,10a,10b-decahydro-2,3-dihydroxy-1a,5,8-trimethyl-9-oxooxireno[9,10]cyclodeca[1,2-b]furan-7-yl] ester
CAS No.	62197-54-0
Molecular Formula	C21H28O7
Molecular Weight	392.45 g/mol
Synonyms	Artemisinin tiglate; Dihydroartemisinin tiglate; Dihydroartemisinin tiglic acid ester; Tiglic acid dihydroartemisinin ester; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-yl (2E)-2-methyl-2-butenoate; Arteether analog; Artemisinin derivative ester; Tiglate ester of dihydroartemisinin
EINECS	Contact for details

Quality Control

Our (E)-2-Methyl-2-butenoic acid dihydroartemisinin ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. Due to its hygroscopic nature, the container should be kept in a desiccated environment and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.