Description

(5S,8R,9S,11bR)-6a,7,7aα,8,10,11-Hexahydro-8-hydroxy-2',2',5,6aβ,8-pentamethylspiro[5,11aα-methano-11aH-fluoreno[4,4a-c]furan-9(3H),3'(6'H)-[2H]pyran]-3,6,6'-trione is a high-purity, complex spirocyclic diterpenoid compound of significant interest in advanced organic synthesis. This compound serves as a critical chiral intermediate and scaffold for the development of novel bioactive molecules. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and fine chemical industries for its unique structural framework.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in steroid and terpenoid-based therapeutic research.
• Agrochemical Research: Used as a precursor in the development of new plant growth regulators or pesticides with specific stereochemical activity.
• Organic Synthesis Reagent: A valuable starting material for complex natural product synthesis and methodology development due to its intricate spirocyclic and polycyclic structure.
• Biochemical Research: Potential use as a probe or ligand in studying enzyme interactions and biological pathways related to terpenoid metabolism.
• Fine Chemical Production: Serves as a specialty intermediate for manufacturing high-value, low-volume chemicals requiring precise stereochemistry.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in synthetic organic chemistry and stereochemistry.

Basic Information

Item	Details
Product Name	(5S,8R,9S,11bR)-6a,7,7aα,8,10,11-Hexahydro-8-hydroxy-2',2',5,6aβ,8-pentamethylspiro[5,11aα-methano-11aH-fluoreno[4,4a-c]furan-9(3H),3'(6'H)-[2H]pyran]-3,6,6'-trione
CAS No.	60451-42-5
Molecular Formula	C27H34O6
Molecular Weight	454.56 g/mol
Synonyms	6a,7,7aα,8,10,11-Hexahydro-8-hydroxy-2',2',5,6aβ,8-pentamethylspiro[5,11aα-methano-11aH-fluoreno[4,4a-c]furan-9(3H),3'(6'H)-[2H]pyran]-3,6,6'-trione; Spiro[5,11aα-methano-11aH-fluoreno[4,4a-c]furan-9(3H),3'(6'H)-[2H]pyran] derivative; CAS 60451-42-5; (5S,8R,9S,11bR)-form; Pentamethylspirofluorenofuranpyran-trione
EINECS	Contact for details

Quality Control

Our (5S,8R,9S,11bR)-6a,7,7aα,8,10,11-Hexahydro-8-hydroxy-2',2',5,6aβ,8-pentamethylspiro[5,11aα-methano-11aH-fluoreno[4,4a-c]furan-9(3H),3'(6'H)-[2H]pyran]-3,6,6'-trione is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. Products undergo rigorous analytical testing, including HPLC, NMR, and chiral analysis, to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.