Description

Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 8-cyclopentyl-2-[[5-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]-2-pyridinyl]amino]-7,8-dihydro-5-methyl-7-oxo-, ethyl ester is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of targeted kinase inhibitors. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel therapeutic agents. The precise molecular architecture of this intermediate makes it a valuable building block for creating potent and selective drug candidates.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and development of kinase inhibitor drugs for oncology and other therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization.
• Biochemical Tool Compound: Serves as a reference standard or probe molecule in enzymatic assays and target validation studies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	Pyrido[2,3-d]pyrimidine-6-carboxylic acid, 8-cyclopentyl-2-[[5-[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]-2-pyridinyl]amino]-7,8-dihydro-5-methyl-7-oxo-, ethyl ester
CAS No.	571189-03-2
Molecular Formula	C31H41N7O5
Molecular Weight	591.70 g/mol
Synonyms	Ethyl 8-cyclopentyl-2-({5-[4-(tert-butoxycarbonyl)piperazin-1-yl]pyridin-2-yl}amino)-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate; BOC-Pyrido-pyrimidine Intermediate; 571189-03-2; UNII-9P3C8WJ3QN; 9P3C8WJ3QN; Kinase Inhibitor Intermediate CAS 571189-03-2; Tert-butyl 4-(6-((8-cyclopentyl-6-(ethoxycarbonyl)-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up work. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and LC-MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support compliance with ICH guidelines for impurity identification and qualification.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound may be hygroscopic (moisture-sensitive); keep the original container tightly sealed under inert atmosphere if specified. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0%
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.