Description

(2S,1S,3'R,4'bS,8'aS,9'S,10'S)-3'-Acetoxy-4'b,5',6',7',8',8'a,9',10'-octahydro-9',10'-dihydroxy-2,4'b,8',8'-tetramethylspiro[cyclopropane-1,2'(1'H)-phenanthrene]-1',4'(3'H)-dione is a complex, high-purity steroidal derivative with a unique spirocyclic and cyclopropane-fused structure. This compound is of significant interest for advanced pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents. It serves as a critical chiral intermediate or reference standard for researchers in medicinal chemistry, process development, and analytical laboratories.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel steroid-based drugs and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of new therapeutic candidates targeting hormone receptors.
• Reference Standard: Serves as a high-purity analytical standard for quality control, method development, and regulatory submissions.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex steroidal molecules.
• Biochemical Research: Used as a tool compound to study enzyme interactions and metabolic pathways involving steroidal substrates.

Basic Information

Product Name	(2S,1S,3'R,4'bS,8'aS,9'S,10'S)-3'-Acetoxy-4'b,5',6',7',8',8'a,9',10'-octahydro-9',10'-dihydroxy-2,4'b,8',8'-tetramethylspiro[cyclopropane-1,2'(1'H)-phenanthrene]-1',4'(3'H)-dione
CAS No.	56197-49-0
Molecular Formula	C24H34O6
Molecular Weight	418.53 g/mol
Synonyms	3'-Acetoxy-9',10'-dihydroxy-2,4'b,8',8'-tetramethylspiro[cyclopropane-1,2'(1'H)-phenanthrene]-1',4'(3'H)-dione; 9',10'-Dihydroxy-3'-acetoxy-2,4'b,8',8'-tetramethylspiro[cyclopropane-1,2'(1'H)-phenanthrene]-1',4'(3'H)-dione; Spiro[cyclopropane-1,2'(1'H)-phenanthrene] dione derivative; Steroidal spirocyclic dione; (1'S,2S,3'R,4'bS,8'aS,9'S,10'S)-3'-Acetoxy-9',10'-dihydroxy-2,4'b,8',8'-tetramethyl-1',2',3',4',4'a,4'b,5',6',7',8',8'a,9',10',10'a-tetradecahydrospiro[cyclopropane-1,2'-phenanthrene]-1',4'(3'H)-dione
EINECS	Contact for details

Quality Control

Our (2S,1S,3'R,4'bS,8'aS,9'S,10'S)-3'-Acetoxy-4'b,5',6',7',8',8'a,9',10'-octahydro-9',10'-dihydroxy-2,4'b,8',8'-tetramethylspiro[cyclopropane-1,2'(1'H)-phenanthrene]-1',4'(3'H)-dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the stringent requirements for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Chiral Purity	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.