Description

N2-[2-Acetylamino-4-O-[2-acetylamino-3-O,4-O,6-O-tris(trimethylsilyl)-2-deoxy-β-D-glucopyranosyl]-3-O,6-O-bis(trimethylsilyl)-2-deoxy-β-D-glucopyranosyl]-L-asparagine is a sophisticated, fully protected glycosyl asparagine derivative, serving as a critical advanced intermediate in complex carbohydrate synthesis. Its value lies in providing a pre-assembled, silyl-protected building block that streamlines the production of structurally defined glycopeptides and oligosaccharides, saving significant research and development time. This compound is essential for pharmaceutical researchers and fine chemical manufacturers focused on developing novel glycoconjugate therapeutics, vaccines, and diagnostic tools.

Application

• Glycopeptide Synthesis: As a key protected intermediate for the solid-phase or solution-phase synthesis of N-linked glycopeptides, mimicking natural biological structures.
• Oligosaccharide Assembly: A crucial building block for the chemical or chemoenzymatic synthesis of complex, biologically active oligosaccharides.
• Pharmaceutical Research: Used in the discovery and development of new glycoprotein-based drugs, including monoclonal antibodies and enzyme replacement therapies.
• Vaccine Development: Employed in the construction of synthetic carbohydrate antigens for conjugate vaccine candidates against bacterial and viral pathogens.
• Chemical Biology Probes: Serves as a precursor for labeled glycoconjugates used to study carbohydrate-protein interactions and cell signaling pathways.
• Process Chemistry: An intermediate in the scaled-up GMP production of active pharmaceutical ingredients (APIs) that contain glycosylated asparagine motifs.

Basic Information

Product Name	N2-[2-Acetylamino-4-O-[2-acetylamino-3-O,4-O,6-O-tris(trimethylsilyl)-2-deoxy-β-D-glucopyranosyl]-3-O,6-O-bis(trimethylsilyl)-2-deoxy-β-D-glucopyranosyl]-L-asparagine
CAS No.	56051-47-9
Molecular Formula	C40H81N3O15Si5
Molecular Weight	~984.6 g/mol
Synonyms	N-[(2S)-4-Amino-1-[[(2R,3R,4S,5R,6R)-4-[(2R,3R,4S,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]amino]-1,4-dioxobutan-2-yl]acetamide (fully deprotected form); L-Asparagine, N2-[2-(acetylamino)-4-O-[2-(acetylamino)-3,4,6-tris-O-(trimethylsilyl)-2-deoxy-β-D-glucopyranosyl]-3,6-bis-O-(trimethylsilyl)-2-deoxy-β-D-glucopyranosyl]-; Fully Silylated Glycosyl Asparagine; Protected Glycosylamino Acid; Glycopeptide Building Block; TMS-protected GlcNAc-Asn derivative.
EINECS	Contact for details

Quality Control

Every batch of this advanced synthetic intermediate is produced and analyzed under strict quality control protocols to ensure consistency and purity for sensitive research and development applications. Our standard analytical package includes HPLC for purity assessment, NMR (1H & 13C) for structural confirmation, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.