Description

(R)-2-Methyl-2-oxiranecarboxylic acid (3aR,4β,6aβ,8α,9R,9aβ,9bα)-decahydro-8-hydroxy-3,6-bis(methylene)-2-oxospiro[azuleno[4,5-b]furan-9(9aH),2'-oxirane]-4-yl ester is a highly functionalized, complex sesquiterpene lactone derivative, valued for its intricate stereochemistry and reactive epoxide moiety. This compound serves as a critical advanced pharmaceutical intermediate and a versatile chiral building block for the synthesis of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of targeted therapeutics, including anti-inflammatory and anti-cancer agents.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel drug candidates, particularly in oncology and immunology research.
• Medicinal Chemistry Research: Used as a complex scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Chemical Biology Probes: Serves as a starting material for developing activity-based probes to study enzyme function and biological pathways.
• Asymmetric Synthesis: Utilized as a sophisticated chiral template or reagent in stereoselective organic synthesis.
• Natural Product Analog Synthesis: Core structure for the semi-synthesis of analogs based on sesquiterpene lactone natural products.

Basic Information

Product Name	(R)-2-Methyl-2-oxiranecarboxylic acid (3aR,4β,6aβ,8α,9R,9aβ,9bα)-decahydro-8-hydroxy-3,6-bis(methylene)-2-oxospiro[azuleno[4,5-b]furan-9(9aH),2'-oxirane]-4-yl ester
CAS No.	55399-34-3
Molecular Formula	C20H24O6
Molecular Weight	360.40 g/mol
Synonyms	2-Methyloxirane-2-carboxylic acid (1aR,2S,3aS,4S,7aS,7bS)-decahydro-2-hydroxy-4,7-bis(methylene)-1H-cyclopropa[3,4]cyclopenta[1,2-c]furan-1-yl ester; Parthenolide derivative; Parthenolide epoxide ester; Spiro[azuleno[4,5-b]furan-9(9aH),2'-oxirane] derivative; (3aR,4β,6aβ,8α,9R,9aβ,9bα)-Decahydro-8-hydroxy-3,6-bis(methylene)-2-oxospiro[azuleno[4,5-b]furan-9(9aH),2'-oxirane]-4-yl (R)-2-methyloxirane-2-carboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.