Description

(1S,2S,3'R,4'bS,7'R,9'S,10'S)-4'b,5',6',7',8',8'aβ,9',10'-Octahydro-3',9',10'-trihydroxy-2,4'b,7'-trimethyl-8'-methylenespiro[cyclopropane-1,2'(1'H)-phenanthrene]-1',4'(3'H)-dione is a complex, high-purity steroidal compound with a unique spirocyclic structure. This molecule is of significant interest in advanced pharmaceutical research and development due to its intricate stereochemistry and potential as a key synthetic intermediate or pharmacophore. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of novel steroid-based therapeutics. The compound's specific stereochemistry is critical for its biological activity and interaction with target receptors.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the multi-step synthesis of novel steroid-based drugs targeting hormonal regulation, inflammation, or metabolic pathways.
• Biochemical Research: Used as a reference standard or probe in studies investigating steroid receptor binding affinity, enzyme inhibition, and metabolic pathways.
• Process Chemistry Development: Employed in route scouting and optimization for the efficient, scalable production of complex steroidal active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis, particularly in stereoselective reactions and spirocycle formation.
• Pre-clinical Studies: May be formulated for use in in vitro and in vivo studies to evaluate pharmacokinetic and pharmacodynamic properties of new chemical entities.

Basic Information

Item	Details
Product Name	(1S,2S,3'R,4'bS,7'R,9'S,10'S)-4'b,5',6',7',8',8'aβ,9',10'-Octahydro-3',9',10'-trihydroxy-2,4'b,7'-trimethyl-8'-methylenespiro[cyclopropane-1,2'(1'H)-phenanthrene]-1',4'(3'H)-dione
CAS No.	51787-41-8
Molecular Formula	C23H32O5
Molecular Weight	388.50 g/mol
Synonyms	9α,11α-Epoxy-17β-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic Acid γ-Lactone; 9α,11α-Epoxy-17β-hydroxy-3-oxo-17α-pregna-4-ene-7α,21-dicarboxylic Acid γ-Lactone; 7α,21:9α,11α-Diepoxy-17β-hydroxy-4-pregnene-3,20-dione; Canrenone Impurity; Spiro[cyclopropane-1,2'(1'H)-phenanthrene]-1',4'(3'H)-dione derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for research and development applications. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to confirm identity, stereochemical purity, and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to ensure traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which may affect stability and handling properties. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.