Description

N1-(5-chloropyridin-2-yl)-N2-((1R,2R,4R)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide 4-methylbenzenesulfonate is a high-purity, non-racemic chiral compound designed for advanced pharmaceutical research and development. This molecule is of significant interest for its potential as a key intermediate or active pharmaceutical ingredient (API) in the discovery of novel therapeutics. It is primarily targeted at research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in medicinal chemistry, preclinical studies, and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies, lead optimization, and the development of new chemical entities (NCEs).
• Preclinical Development: Employed in the formulation of drug substances for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Process Chemistry & Scale-Up: Acts as a reference standard and starting material for developing robust, scalable synthetic routes under GMP conditions.
• Biochemical Assay Development: Utilized as a ligand or inhibitor in high-throughput screening (HTS) campaigns to identify novel biological targets.
• Academic Research: Supports chemical biology and organic synthesis projects in university and institutional laboratories.

Basic Information

Product Name	N1-(5-chloropyridin-2-yl)-N2-((1R,2R,4R)-4-(dimethylcarbamoyl)-2-(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamido)cyclohexyl)oxalamide 4-methylbenzenesulfonate
CAS No.	2852734-46-2
Molecular Formula	C31H36ClN7O6S2
Molecular Weight	710.24 g/mol
Synonyms	(1R,2R,4R)-N1-(5-Chloro-2-pyridinyl)-N2-[2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]-4-(dimethylaminocarbonyl)cyclohexyl]ethanediamide 4-methylbenzenesulfonate; Oxalamide derivative 2852734-46-2; Chiral thiazolopyridine carboxamide tosylate; (R,R,R)-Enantiomer oxalamide tosylate salt; Pharmaceutical intermediate CAS 2852734-46-2
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. We employ advanced analytical techniques including HPLC, NMR, and MS to verify identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. For development projects requiring regulatory support, we can provide material manufactured under a quality management system aligned with ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.