Description

2-amino-2-(hydroxymethyl)propane-1,3-diol (S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate is a high-purity, complex organic intermediate of significant interest in advanced pharmaceutical research and development. This compound is critical for medicinal chemists exploring novel therapeutic agents, particularly in targeted drug discovery programs. Its sophisticated molecular architecture makes it a valuable building block for synthesizing potential active pharmaceutical ingredients (APIs) targeting specific disease pathways.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a sophisticated scaffold or building block in structure-activity relationship (SAR) studies and lead optimization for novel drug candidates.
• Targeted Therapy Development: Its specific structural motifs suggest potential application in the synthesis of compounds for oncology, neurology, or immunology research programs.
• Process Chemistry & Scale-up: Employed in route scouting, process development, and the pilot-scale synthesis of investigational drugs under Good Laboratory Practice (GLP) or current Good Manufacturing Practice (cGMP) conditions.
• Bioconjugation & Probe Synthesis: Can be utilized in the development of chemical probes, diagnostic agents, or antibody-drug conjugates (ADCs) due to its functionalized structure.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs engaged in custom synthesis and development services for the global pharmaceutical industry.

Basic Information

Product Name	2-amino-2-(hydroxymethyl)propane-1,3-diol (S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate
CAS No.	2230198-03-3
Molecular Formula	C34H35FN5O5
Molecular Weight	605.68 g/mol
Synonyms	(S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylic acid; 2-Amino-2-methyl-1,3-propanediol derivative; Tris base derivative; Benzimidazole-piperidine conjugate; Fluorobenzyloxypyridine intermediate; Oxetane-containing pharmaceutical intermediate; CAS 2230198-03-3
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality management systems. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality protocols are designed to meet the exacting standards of pharmaceutical R&D, ensuring consistent batch-to-batch reproducibility and reliability for your critical synthesis work. Specifications can be aligned with client-specific requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to maintain stability. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.