Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-4-amino-5-(aminocarbonyl)-1H-pyrrol-3-yl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)- is a complex, high-purity synthetic intermediate featuring a protected carboxylic acid group and a silyl ether moiety, designed for advanced chemical synthesis. This compound is critical for researchers and manufacturers requiring precise stereochemistry and functional group manipulation in multi-step organic reactions. Its primary value lies in serving as a key building block for the development of novel pharmaceuticals, particularly in nucleoside and heterocyclic chemistry, where its specific stereoconfiguration is essential for biological activity.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel antiviral or anticancer nucleoside analogs.
• ProTide Prodrug Technology: Used in the research and development of ProTide prodrugs, which enhance the intracellular delivery of nucleotide analogs.
• Medicinal Chemistry Research: Serves as a sophisticated building block for constructing complex heterocyclic scaffolds in drug discovery programs.
• Process Chemistry Development: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Utilized in the synthesis of labeled or modified nucleotides for studying biological mechanisms.

Basic Information

Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-4-amino-5-(aminocarbonyl)-1H-pyrrol-3-yl-6-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-
CAS No.	222631-53-0
Molecular Formula	C24H38N4O7Si
Molecular Weight	522.68 g/mol
Synonyms	tert-Butyl (3aS,4S,6R,6aR)-4-(4-amino-5-carbamoyl-1H-pyrrol-3-yl)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; (3aS,4S,6R,6aR)-4-(4-Amino-5-carbamoyl-1H-pyrrol-3-yl)-6-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester; 1,1-Dimethylethyl (3aS,4S,6R,6aR)-4-[4-amino-5-(aminocarbonyl)-1H-pyrrol-3-yl]-6-[[(1,1-dimethylethyl)dimethylsilyl]oxymethyl]tetrahydro-2,2-dimethyl-3aH-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; 5H-1,3-Dioxolo[4,5-c]pyrrole-5-carboxylic acid, 4-[4-amino-5-(aminocarbonyl)-1H-pyrrol-3-yl]-6-[[(1,1-dimethylethyl)dimethylsilyl]oxymethyl]tetrahydro-2,2-dimethyl-, 1,1-dimethylethyl ester, (3aS,4S,6R,6aR)-; TBDMS-protected nucleoside intermediate; ProTide intermediate precursor.
EINECS	Contact for details

Quality Control

This high-value synthetic intermediate is produced under strict quality control protocols in facilities that adhere to cGMP (current Good Manufacturing Practice) standards. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and stereochemical integrity. Comprehensive Certificates of Analysis (COA) detailing all critical quality attributes are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas when necessary to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.