Description

2H-Cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, 2-[3-[(acetyloxy)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-3,4,7,8-tetrahydro-7,7-dimethyl- is a sophisticated, high-value pharmaceutical intermediate featuring a pinacol boronate ester functional group, which is critical for modern cross-coupling reactions in drug synthesis. This compound is engineered to serve as a key building block in the development of novel, targeted therapeutic agents, enabling precise molecular construction. It is primarily sought after by R&D teams and process chemists in the pharmaceutical and biotechnology sectors for advanced medicinal chemistry programs.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a versatile boronic ester reagent for constructing complex biaryl and heterobiaryl scaffolds central to many drug candidates.
• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for oncology, CNS, and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Development & Scale-Up: Serves as a key material for developing robust, scalable synthetic routes from laboratory to pilot plant scale.
• Bioconjugation & Probe Synthesis: Potential use in creating chemical probes or tagged molecules for biochemical and diagnostic research.

Basic Information

Product Name	2H-Cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, 2-[3-[(acetyloxy)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-3,4,7,8-tetrahydro-7,7-dimethyl-
CAS No.	1899834-77-5
Molecular Formula	C27H34BN3O5
Molecular Weight	491.39 g/mol
Synonyms	2-(3-(Acetoxymethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one; 2-[3-[(Acetyloxy)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-3,4,7,8-tetrahydro-7,7-dimethyl-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one; (2-(7,7-Dimethyl-1-oxo-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-2-yl)-3-(hydroxymethyl)pyridin-4-yl)boronic acid pinacol ester acetate; CAS 1899834-77-5; Boronate Ester Intermediate 1899834-77-5
EINECS	Contact for details

Quality Control

This high-purity intermediate is manufactured under cGMP-compliant conditions to ensure batch-to-batch consistency and reliability for critical research and development applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and LC-MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opened to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.