Description

1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, 3-[2-[[(1R,2S,5R)-7-oxo-6-(phenylmethoxy)-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl]hydrazide], (3R)- is a high-purity, advanced pharmaceutical intermediate with a complex, stereochemically defined bicyclic structure. This compound is critical for the synthesis of novel β-lactamase inhibitors and other sophisticated active pharmaceutical ingredients (APIs) targeting resistant bacterial infections. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation antibacterial therapies.

Application

• Key Intermediate for β-Lactamase Inhibitors: Serves as a crucial building block in the synthesis of new-generation diazabicyclooctane (DBO) class inhibitors like avibactam and relebactam analogs.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of novel antibacterial agents.
• Process Chemistry & Scale-Up: Employed in the development and optimization of commercial-scale synthetic routes for complex API molecules.
• Combinatorial Chemistry: A valuable scaffold for creating focused libraries of compounds for high-throughput screening against bacterial targets.
• Academic Research: Utilized in biochemical and microbiological studies to understand mechanisms of bacterial resistance and inhibition.

Basic Information

Item	Details
Product Name	1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, 3-[2-[[(1R,2S,5R)-7-oxo-6-(phenylmethoxy)-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl]hydrazide], (3R)-
CAS No.	1436861-98-1
Molecular Formula	C25H35N5O6
Molecular Weight	501.58 g/mol
Synonyms	(3R)-1-(tert-Butyl) 3-(2-((2S,5R)-7-oxo-6-(benzyloxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)ethyl) piperidine-1,3-dicarboxylate; tert-Butyl 3-[(2-{[(2S,5R)-7-oxo-6-(phenylmethoxy)-1,6-diazabicyclo[3.2.1]oct-2-yl]carbonyl}hydrazinyl)carbonyl]piperidine-1-carboxylate; Avibactam Advanced Intermediate; DBO Derivative Intermediate; (3R)-1-Boc-3-((2-((2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]oct-2-yl)formamido)ethyl)piperidine-1,3-dicarboxylic acid 1-tert-butyl ester
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict GMP (Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Our quality assurance includes rigorous in-process controls and comprehensive final release testing. Certificates of Analysis (COA) are provided with each batch, detailing purity, chiral purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.