Description

2(1H)-Pyridinone, 1-methyl-3-[[5-[(2S)-2-methyl-4-(3-oxetanyl)-1-piperazinyl]-2-pyridinyl]amino]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- is a sophisticated, high-purity pharmaceutical intermediate featuring a unique piperazinyl-pyridinyl scaffold and a boronic ester pinacol group. This compound is of critical importance for medicinal chemistry research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and advanced contract research organizations (CROs) engaged in the discovery of novel enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex small molecule drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile reactive sites.
• Protease Inhibitor Development: The boronic ester moiety makes it a valuable precursor for developing serine protease inhibitors, a crucial class for treating various diseases.
• Kinase Inhibitor Synthesis: The heterocyclic core structure is applicable in creating novel kinase inhibitors for oncology and inflammatory disease research.
• Bioconjugation and Probe Development: Potential use in creating chemical probes for biochemical assays and diagnostic applications via the reactive boronate group.
• Pre-clinical Drug Development: Serves as a critical material for producing batches of candidate compounds for pre-clinical pharmacological and toxicological evaluation.

Basic Information

Product Name	2(1H)-Pyridinone, 1-methyl-3-[[5-[(2S)-2-methyl-4-(3-oxetanyl)-1-piperazinyl]-2-pyridinyl]amino]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CAS No.	1433849-83-2
Molecular Formula	C25H38BN5O4
Molecular Weight	483.41 g/mol
Synonyms	1-Methyl-3-((5-((S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one; (S)-1-Methyl-3-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one; CAS 1433849-83-2; Boronic acid pinacol ester intermediate; Piperazinyl-pyridine boronate.
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols in facilities adhering to cGMP guidelines. Every batch is characterized using advanced analytical techniques including HPLC, NMR (1H, 13C, 11B), and Mass Spectrometry to ensure structural identity and purity. Comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.