Description

2-Chloropyridine-5-boronic acid MIDA ester, 6-Chloro-3-pyridineboronic acid MIDA ester, 2-(6-Chloro-3-pyridinyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione is a high-value, protected boronic acid derivative designed for advanced synthetic chemistry. This compound matters because the MIDA (N-methyliminodiacetic acid) ester group provides exceptional stability, enabling complex multi-step synthesis and purification protocols that are challenging with free boronic acids. It is primarily needed by pharmaceutical and agrochemical R&D teams for the efficient construction of complex molecules via Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing functionalized pyridine scaffolds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, insecticides, and fungicides that require chloropyridine motifs.
• Material Science Research: Serves as a precursor for creating organic electronic materials, ligands for catalysis, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: The protected boronate ester is specifically engineered for reliable, iterative cross-coupling reactions in complex molecule assembly.
• Chemical Library Development: Enables the efficient, parallel synthesis of diverse compound libraries for high-throughput screening in drug discovery.
• Process Chemistry & Scale-up: Its enhanced stability makes it suitable for developing robust and scalable manufacturing routes for target molecules.

Basic Information

Product Name	2-Chloropyridine-5-boronic acid MIDA ester, 6-Chloro-3-pyridineboronic acid MIDA ester, 2-(6-Chloro-3-pyridinyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
CAS No.	1257642-71-9
Molecular Formula	C11H10BClN2O4
Molecular Weight	280.47 g/mol
Synonyms	6-Chloro-3-pyridineboronic acid MIDA ester; 2-(6-Chloro-3-pyridinyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione; 2-Chloro-5-pyridylboronic acid MIDA ester; (6-Chloropyridin-3-yl)boronic acid MIDA ester; MIDA Boronate Ester of 6-Chloro-3-pyridineboronic acid; 6-Chloro-3-pyridinylboronic acid MIDA ester; 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine MIDA adduct (related protected form).
EINECS	Contact for details

Quality Control

Our 2-Chloropyridine-5-boronic acid MIDA ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for critical cross-coupling applications. Certificates of Analysis (COA) with full specification data are provided to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.