Description

(3S,6R,7S,8S,12Z,15S,16E)-1,3,15-TRIS-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-7-HYDROXY-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)HEPTADECYL-12,16-DIEN-5-ONE is a complex, highly functionalized polyketide-derived compound featuring multiple stereocenters and protective groups. This molecule is of significant interest as a key synthetic intermediate in the production of advanced pharmaceutical agents, particularly macrolide antibiotics and other bioactive natural product analogs. It is essential for research and development chemists in the pharmaceutical and fine chemical sectors who require high-purity, structurally defined building blocks for complex total synthesis and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Critical precursor in the multi-step synthesis of novel macrolide antibiotics and other complex therapeutic agents.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and the development of new drug candidates.
• Total Synthesis: Serves as a pivotal advanced intermediate in the academic and industrial total synthesis of complex natural products.
• Biochemical Tool Compound: Potential use in probing biological pathways and enzyme mechanisms due to its specific stereochemistry and functional groups.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for high-value target molecules.

Basic Information

Product Name	(3S,6R,7S,8S,12Z,15S,16E)-1,3,15-TRIS-{[TERT-BUTYL(DIMETHYL)SILYL]OXY}-7-HYDROXY-4,4,6,8,12,16-HEXAMETHYL-17-(2-METHYL-1,3-THIAZOL-4-YL)HEPTADECYL-12,16-DIEN-5-ONE
CAS No.	193146-49-5
Molecular Formula	C46H87NO6SSi3
Molecular Weight	862.5 g/mol
Synonyms	1,3,15-Tris-O-(tert-butyldimethylsilyl)-7-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-4-thiazolyl)-5-oxo-12,16-heptadienoic Acid Derivative; TBS-protected Polyketide Intermediate; CAS 193146-49-5; Advanced Macrolide Synthesis Intermediate; (12Z,16E)-Isomer of TBS-protected Aglycone; 5-Keto Polyene Thiazole Derivative; Silyl Ether Protected Hydroxy Ketone
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and structural integrity. Identity and purity are confirmed through a suite of analytical techniques including HPLC, NMR (1H & 13C), and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, stereochemical confirmation, and impurity profile is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or moisture will lead to decomposition. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.