Description

5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-6-(3-nitrophenyl)-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)- is a sophisticated, stereochemically defined synthetic intermediate of significant value in advanced organic synthesis. This compound matters because its complex molecular architecture, featuring a protected carboxylic acid group and a nitrophenyl moiety, makes it a critical building block for constructing more complex pharmacologically active molecules. Pharmaceutical research and development organizations need this high-purity intermediate for the synthesis of novel active pharmaceutical ingredients (APIs) and for use in medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of potential drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its modifiable functional groups.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for new chemical entities (NCEs).
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CRMOs) producing specialized compounds for clients.
• Academic Research: Utilized in university and institutional labs for developing new synthetic methodologies involving complex heterocycles and protecting group strategies.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in API manufacturing.

Basic Information

Item	Details
Product Name	5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid, 4-(1,1-dimethylethyl)dimethylsilyloxymethyltetrahydro-2,2-dimethyl-6-(3-nitrophenyl)-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)-
CAS No.	188744-93-6
Molecular Formula	C26H39NO7Si
Molecular Weight	505.69 g/mol
Synonyms	(3aR,4R,6S,6aS)-4-[(tert-Butyldimethylsilyloxy)methyl]-2,2-dimethyl-6-(3-nitrophenyl)tetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylic acid tert-butyl ester; tert-Butyl (3aR,4R,6S,6aS)-4-((tert-butyldimethylsilyloxy)methyl)-2,2-dimethyl-6-(3-nitrophenyl)tetrahydro-5H-[1,3]dioxolo[4,5-c]pyrrole-5-carboxylate; 5H-[1,3]Dioxolo[4,5-c]pyrrole-5-carboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydro-2,2-dimethyl-6-(3-nitrophenyl)-, 1,1-dimethylethyl ester, (3aR,4R,6S,6aS)-; TBS-protected pyrrolidine dioxolane carboxylate nitroarene intermediate.
EINECS	Contact for details

Quality Control

Our 5H-1,3-Dioxolo4,5-cpyrrole-5-carboxylic acid tert-butyl ester intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client requirements or internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep away from strong bases and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.