Description

Spirocyclohexane-1,2-1,3dioxino4,5,6-hiindolizin-9-ol, 8-(1,1-dimethylethyl)dimethylsilyloxyoctahydro-, methanesulfonate (ester), 3aS-(3a.alpha.,8.alpha.,9.alpha.,9a.beta.,9b.alpha.)- is a high-purity, complex organic intermediate featuring a unique spirocyclic and heterocyclic fused ring system. This compound is of significant value in advanced pharmaceutical research and development, particularly for its potential as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors for creating new molecular entities with targeted biological activity.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) or anti-infective applications.
• Medicinal Chemistry Research: Used as a scaffold or building block for constructing compound libraries in high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of target molecules under current Good Manufacturing Practice (cGMP) guidelines.
• Asymmetric Synthesis: Its defined stereochemistry (3aS-) makes it valuable for chiral synthesis, enabling the production of enantiomerically pure final compounds.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying biological pathways and target validation.
• Fine Chemical Synthesis: Acts as a specialized intermediate for synthesizing other complex, high-value fine chemicals and functional materials.

Basic Information

Product Name	Spirocyclohexane-1,2-1,3dioxino4,5,6-hiindolizin-9-ol, 8-(1,1-dimethylethyl)dimethylsilyloxyoctahydro-, methanesulfonate (ester), 3aS-(3a.alpha.,8.alpha.,9.alpha.,9a.beta.,9b.alpha.)-
CAS No.	185899-33-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(3aS)-8-[(tert-Butyldimethylsilyl)oxy]-1,2,3,3a,4,5,8,9,9a,9b-decahydrospiro[cyclohexane-1,7'-indolizine]-9-yl methanesulfonate; 3aS-(3a.alpha.,8.alpha.,9.alpha.,9a.beta.,9b.alpha.)-8-[(1,1-Dimethylethyl)dimethylsilyl]oxy]octahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-9-ol methanesulfonate; tert-Butyldimethylsilyl ether of a spirocyclic indolizine methanesulfonate; CAS 185899-33-6; Spirocyclic indolizine derivative; TBS-protected spirocyclic alcohol mesylate.
EINECS	Contact for details

Quality Control

Our high-purity chemical intermediates are manufactured and tested under a strict quality management system. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing key parameters such as assay, impurity profile, and chiral purity. Our production can align with ISO and cGMP standards for applications requiring rigorous quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.