Description

Spirocyclohexane-1,2-1,3dioxino4,5,6-hiindolizin-8-ol, 9-(1,1-dimethylethyl)dimethylsilyloxyoctahydro-, benzoate (ester), 3aS-(3a.alpha.,8.alpha.,9.beta.,9a.beta.,9b.alpha.)- is a complex, high-purity organic intermediate featuring a unique spirocyclic and heterocyclic fused ring system. This compound is valued for its precise stereochemistry and functional group protection, making it a critical building block in advanced synthetic chemistry. It is primarily sought by pharmaceutical R&D and fine chemical synthesis teams for the development of novel active pharmaceutical ingredients (APIs) and other high-value specialty molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for complex target molecules.
• Advanced Organic Synthesis: Serves as a sophisticated building block for constructing complex natural product analogs and molecular scaffolds in academic and industrial research.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of high-value fine chemicals.
• Protecting Group Chemistry: The tert-butyldimethylsilyl (TBDMS) ether moiety allows for selective protection of hydroxyl groups during multi-step syntheses.
• Chemical Biology Probes: Potential use in the synthesis of labeled compounds or probes for studying biological mechanisms and target engagement.

Basic Information

Product Name	Spirocyclohexane-1,2-1,3dioxino4,5,6-hiindolizin-8-ol, 9-(1,1-dimethylethyl)dimethylsilyloxyoctahydro-, benzoate (ester), 3aS-(3a.alpha.,8.alpha.,9.beta.,9a.beta.,9b.alpha.)-
CAS No.	156206-12-1
Molecular Formula	C29H41NO5Si
Molecular Weight	511.73 g/mol
Synonyms	9-[(1,1-Dimethylethyl)dimethylsilyl]oxy-3a,4,5,6,7,8,9,9a-octahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-8-yl benzoate; 9-(tert-Butyldimethylsilyloxy)octahydrospiro[cyclohexane-1,2'-[1,3]dioxino[4,5,6-hi]indolizin]-8-ol benzoate; (3aS,8R,9S,9aR,9bS)-9-[(tert-Butyldimethylsilyl)oxy]-1,2,3,3a,4,5,6,7,8,9,9a,9b-dodecahydrospiro[cyclohexane-1,2'-pyrano[3',4':5,6]pyrido[1,2-a]indol]-8-yl benzoate; CAS 156206-12-1; TBDMS-protected spirocyclic indolizine benzoate; Spirocyclic TBDMS ether benzoate intermediate.
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity required for sensitive synthetic applications. Our rigorous analytical testing includes HPLC, NMR, and MS to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.