Description

(4E,18E)-3',4',5',6'-Tetrahydro-7,9,11,12-tetrahydroxy-6'-(2-hydroxybutyl)-5',6,8,12,27-pentamethyl-20-(2-methylpropyl)spiro[2,24-dioxabicyclo[21.3.1]heptacosa-4,18-diene-25,2'-[2H]pyran]-3,21-dione is a complex spirocyclic polyketide-derived compound with significant biological activity. This high-purity specialty chemical is valued for its role as a key intermediate in advanced pharmaceutical research and development. It is primarily sought by R&D laboratories and manufacturers in the life sciences sector for the synthesis of novel therapeutic agents and as a reference standard for analytical studies.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel macrocyclic drugs targeting specific biological pathways.
• Biochemical Research: Used as a reference standard and probe compound in enzymatic and receptor binding studies due to its complex structure.
• Antibiotic Research: Serves as a precursor or model compound in the development of new antibiotic classes, leveraging its polyketide backbone.
• Chemical Biology: Employed in target identification and validation studies to understand complex cellular interactions.
• Process Development: Used in scaling up synthetic routes for complex natural product analogs in pilot-scale manufacturing.
• Analytical Standard: High-purity grade material is essential for method development and validation in HPLC, LC-MS, and NMR analysis.

Basic Information

Product Name	(4E,18E)-3',4',5',6'-Tetrahydro-7,9,11,12-tetrahydroxy-6'-(2-hydroxybutyl)-5',6,8,12,27-pentamethyl-20-(2-methylpropyl)spiro[2,24-dioxabicyclo[21.3.1]heptacosa-4,18-diene-25,2'-[2H]pyran]-3,21-dione
CAS No.	140221-73-4
Molecular Formula	C₄₀H₆₄O₁₀
Molecular Weight	704.93 g/mol
Synonyms	Spirangien A; Spiroketal Polyketide; L-755,805; Antibiotic L-755,805; Spiroketal Macrolide; (4E,18E)-Spirangien A; Macrocyclic Spiroketal; L755805
EINECS	Contact for details

Quality Control

Our (4E,18E)-3',4',5',6'-Tetrahydro-7,9,11,12-tetrahydroxy-6'-(2-hydroxybutyl)-5',6,8,12,27-pentamethyl-20-(2-methylpropyl)spiro[2,24-dioxabicyclo[21.3.1]heptacosa-4,18-diene-25,2'-[2H]pyran]-3,21-dione is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets rigorous research-grade specifications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.