Description

2-Penten-1-one, 4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-, (2E,4S)- is a highly specialized, advanced pharmaceutical intermediate characterized by its complex steroidal-like structure with multiple chiral centers and protective silyl ether groups. This compound matters as a critical building block in the synthesis of complex bioactive molecules, offering precise stereochemical control for high-value applications. It is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries who require high-purity, structurally defined intermediates for the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex steroid-derived drug candidates and active pharmaceutical ingredients (APIs).
• Organic Synthesis Research: Used in academic and industrial R&D for constructing intricate carbon skeletons and studying stereoselective reactions.
• Process Chemistry Development: Serves as a critical intermediate for optimizing scalable synthetic routes to target molecules in pilot plants and commercial manufacturing.
• Fine Chemical Production: Employed in the manufacture of high-value specialty chemicals where specific stereochemistry and functional group protection are paramount.

Basic Information

Item	Detail
Product Name	2-Penten-1-one, 4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-, (2E,4S)-
CAS No.	115648-68-5
Molecular Formula	C41H72O3Si2
Molecular Weight	669.2 g/mol
Synonyms	(2E,4S)-4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-2-penten-1-one; 4-[(1R,3aS,4E,7aR)-4-[(2E)-2-[(3S,5R)-3,5-Bis[(tert-butyldimethylsilyl)oxy]-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-cyclopropyl-(2E,4S)-2-penten-1-one; Steroid TBS-protected intermediate; CAS 115648-68-5.
EINECS	Contact for details

Quality Control

Our production of this high-purity intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and structural integrity. Products undergo rigorous analytical testing, including HPLC, GC, NMR, and chiral analysis, to confirm identity, purity, and stereochemical composition. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as specified on the label or COA. This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.