Description

(S)-3-(5-Bromo-Pyridin-2-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block of significant importance in modern pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system and other therapeutic areas. It is essential for medicinal chemists and process development scientists in pharmaceutical and biotechnology companies who require reliable, high-quality intermediates for scale-up and commercial manufacturing.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development of new APIs requiring a specific (S)-configured pyrrolidine scaffold.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to introduce complex chiral centers.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing focused libraries and exploring structure-activity relationships (SAR).
• Process Chemistry & Scale-Up: Suitable for optimization and scaling from gram to kilogram quantities under GMP-like conditions for clinical trial material supply.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for client-specific synthesis projects.

Basic Information

Product Name	(S)-3-(5-Bromo-Pyridin-2-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	960289-30-9
Molecular Formula	C14H19BrN2O3
Molecular Weight	343.22 g/mol
Synonyms	tert-Butyl (3S)-3-[(5-bromopyridin-2-yl)oxy]pyrrolidine-1-carboxylate; (S)-1-Boc-3-(5-bromo-2-pyridyloxy)pyrrolidine; 1-(tert-Butoxycarbonyl)-3-[(5-bromo-2-pyridinyl)oxy]-(S)-pyrrolidine; (S)-3-(5-Bromo-2-pyridyloxy)-1-Boc-pyrrolidine; (S)-N-Boc-3-(5-bromopyridin-2-yloxy)pyrrolidine; (S)-1-Boc-3-(5-bromo-pyridin-2-yloxy)-pyrrolidine; (S)-3-(5-Bromo-2-pyridinoxy)-1-(tert-butoxycarbonyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-3-(5-Bromo-Pyridin-2-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure high chemical and chiral purity suitable for demanding pharmaceutical applications. We provide comprehensive analytical data including HPLC purity, chiral purity (enantiomeric excess), and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) are available for every batch, detailing all relevant specifications. Our quality system supports development under ICH guidelines, and custom purity grades can be produced to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under inert atmosphere when handling is required for extended periods to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.