Description

2-(4-(Methoxycarbonyl)Pyridine-3-Yl)Malonic Acid Dimethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its pyridine-malonate hybrid structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and fine chemicals, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking reliable, high-quality intermediates for scale-up and process optimization.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and other targeted therapy research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides due to its reactive diester and heterocyclic functionalities.
• Organic Synthesis Building Block: Serves as a versatile reagent for constructing complex molecular architectures in academic and industrial research.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal-catalyzed reactions and coordination chemistry.
• Material Science Research: Investigated as a monomer or precursor for functional polymers and advanced organic materials.

Basic Information

Product Name	2-(4-(Methoxycarbonyl)Pyridine-3-Yl)Malonic Acid Dimethyl Ester
CAS No.	960114-13-0
Molecular Formula	C13H13NO6
Molecular Weight	279.25 g/mol
Synonyms	Dimethyl 2-(4-(methoxycarbonyl)pyridin-3-yl)malonate; 3-Pyridinecarboxylic acid, 4-(1,3-bis(methoxycarbonyl)-2-yl)-, methyl ester; Methyl 4-(1,3-dimethoxy-1,3-dioxopropan-2-yl)nicotinate; 2-(4-Carbomethoxypyridin-3-yl)malonic acid dimethyl ester; 3-(1,3-Dimethoxy-1,3-dioxopropan-2-yl)isonicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our 2-(4-(Methoxycarbonyl)Pyridine-3-Yl)Malonic Acid Dimethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment supports compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.