Description

2,4-Dichloro-6-Methoxy-1,5-Naphthyridine is a high-value, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its versatile reactivity, where the chlorine atoms serve as excellent leaving groups for nucleophilic aromatic substitution, enabling the precise construction of complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting kinase inhibition or other biological pathways where the 1,5-naphthyridine scaffold is active.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, or insecticides, leveraging its halogenated structure for further functionalization.
• Material Science Research: Serves as a building block for creating novel organic electronic materials, ligands for catalysis, or fluorescent dyes due to its conjugated aromatic system.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce diverse aryl, heteroaryl, or amine functionalities.
• Nucleophilic Aromatic Substitution: The chlorine atoms can be selectively displaced by various nucleophiles (amines, alkoxides) to create a library of diversified 1,5-naphthyridine derivatives for screening.

Basic Information

Product Name	2,4-Dichloro-6-Methoxy-1,5-Naphthyridine
CAS No.	959990-35-3
Molecular Formula	C9H6Cl2N2O
Molecular Weight	229.06 g/mol
Synonyms	6-Methoxy-2,4-dichloro-1,5-naphthyridine; 2,4-Dichloro-6-methoxy-1,5-naphthyridine; 1,5-Naphthyridine, 2,4-dichloro-6-methoxy-; 959990-35-3
EINECS	Contact for details

Quality Control

We supply 2,4-Dichloro-6-Methoxy-1,5-Naphthyridine in high-purity grades suitable for research and process development. Our products undergo rigorous quality testing to ensure batch-to-batch consistency and compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.