Description

1,2,5,6,8,9-Hexahydro-4-Hydroxy-2-Oxo-7H-Pyrido[2,3-D]Azepine-7-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in process development and scale-up of new drug candidates.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, particularly for neurological and psychiatric applications.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring a fused azepine-pyridine scaffold.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale manufacturing of developmental compounds.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial API batches under GMP guidelines.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API production.

Basic Information

Product Name	1,2,5,6,8,9-Hexahydro-4-Hydroxy-2-Oxo-7H-Pyrido[2,3-D]Azepine-7-Carboxylic Acid tert-Butyl Ester
CAS No.	959636-64-7
Molecular Formula	C15H22N2O4
Molecular Weight	294.35 g/mol
Synonyms	tert-Butyl 1,2,5,6,8,9-hexahydro-4-hydroxy-2-oxo-7H-pyrido[2,3-d]azepine-7-carboxylate; 7H-Pyrido[2,3-d]azepine-7-carboxylic acid, 1,2,5,6,8,9-hexahydro-4-hydroxy-2-oxo-, 1,1-dimethylethyl ester; 959636-64-7; BOC-protected pyridoazepine derivative; Hexahydro-4-hydroxy-2-oxo-7H-pyrido[2,3-d]azepine-7-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of 1,2,5,6,8,9-Hexahydro-4-Hydroxy-2-Oxo-7H-Pyrido[2,3-D]Azepine-7-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management systems. The material is manufactured and controlled to meet the exacting standards required for pharmaceutical R&D and GMP manufacturing. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring traceability, consistency, and regulatory compliance for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed to protect this light-sensitive compound from degradation and to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.