Description

3-Bromo-5-(1,3-Dioxolan-2-yl)pyridine is a versatile and high-value brominated pyridine derivative featuring a protected aldehyde functionality. This compound matters as a critical pharmaceutical intermediate and organic synthesis building block, enabling the construction of complex molecules for drug discovery and advanced materials. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogenated heterocyclic core.
• Ligand and Catalyst Development: Serves as a building block for creating sophisticated ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs or molecular wires, due to its conjugated pyridine system.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Chemical Biology Probes: Utilized to create tagged molecules or probes for studying biological pathways and protein interactions.

Basic Information

Product Name	3-Bromo-5-(1,3-Dioxolan-2-yl)pyridine
CAS No.	959623-14-4
Molecular Formula	C8H8BrNO2
Molecular Weight	230.06 g/mol
Synonyms	2-(5-Bromopyridin-3-yl)-1,3-dioxolane; 5-Bromo-3-(1,3-dioxolan-2-yl)pyridine; 3-Bromo-5-(1,3-dioxolan-2-yl)pyridine; Pyridine, 3-bromo-5-(1,3-dioxolan-2-yl)-; 959623-14-4; 3-Bromo-5-(1,3-dioxolan-2-yl)pyridine; 3-Bromo-5-(2-(1,3-dioxolanyl))pyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-(1,3-Dioxolan-2-yl)pyridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.