Description

Phosphonous Acid, p-?(Trimethylsilyl)?-?, Diethyl Ester is a specialized organophosphorus compound featuring a trimethylsilyl-protected phosphonite group. This chemical matters as a valuable intermediate and reagent in advanced organic synthesis, particularly for introducing phosphorus-containing functional groups under controlled conditions. It is needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecules and novel ligands.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and prodrugs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators.
• Ligand Precursor: Serves as a precursor for sophisticated phosphonite and phosphine ligands used in homogeneous catalysis.
• Material Science Research: Employed in the development of flame retardants, specialty polymers, and advanced functional materials.
• Cross-Coupling Reactions: Acts as a reagent in metal-catalyzed cross-coupling reactions to form carbon-phosphorus bonds.
• Process Chemistry: Utilized in scale-up and optimization of synthetic routes in fine chemical manufacturing.

Basic Information

Product Name	Phosphonous Acid, p-?(Trimethylsilyl)?-?, Diethyl Ester
CAS No.	959028-36-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Diethyl (Trimethylsilyl)phosphonite; [(Trimethylsilyl)phosphonous acid] diethyl ester; Phosphonous acid, P-(trimethylsilyl)-, diethyl ester; Diethyl trimethylsilyl phosphonite; TMS-Diethyl Phosphonite; (Trimethylsilyl)diethoxyphosphine; Diethyl (trimethylsilyl)phosphinite
EINECS	Contact for details

Quality Control

Our Phosphonous Acid, p-?(Trimethylsilyl)?-?, Diethyl Ester is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR, GC, and HPLC, to ensure high purity and batch-to-batch consistency suitable for research and process development. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.