Description

3-Pentyn-1-ol, 5-[(trimethylsilyl)oxy]- is a specialized organosilicon-protected alkyne alcohol, a key building block in advanced organic synthesis. This compound matters for its role as a versatile synthon, offering a protected hydroxyl group and a terminal alkyne handle for click chemistry, Sonogashira couplings, and other metal-catalyzed cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures. The product is supplied with a high level of purity and consistency to ensure reliable performance in sensitive synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, particularly in fragment-based drug discovery.
• Agrochemical Synthesis: Used in the research and development of new pesticides, herbicides, and plant growth regulators requiring alkyne functionality.
• Material Science & Polymer Chemistry: A monomer or cross-linking agent for creating specialty polymers, dendrimers, and functionalized surfaces via click chemistry (e.g., CuAAC).
• Ligand & Catalyst Development: Employed in the preparation of novel ligands for transition metal catalysis and organometallic complexes.
• Chemical Biology & Bioconjugation: Facilitates the site-specific labeling of biomolecules (proteins, nucleic acids) through bioorthogonal reactions.
• Organic Synthesis Reagent: A versatile reagent for constructing carbon-carbon bonds and introducing silyl-protected functionalities into complex organic molecules.

Basic Information

Product Name	3-Pentyn-1-ol, 5-[(trimethylsilyl)oxy]-
CAS No.	958752-18-6
Molecular Formula	C8H16O2Si
Molecular Weight	172.30 g/mol
Synonyms	5-[(Trimethylsilyl)oxy]-3-pentyn-1-ol; 5-(Trimethylsilyloxy)pent-3-yn-1-ol; 3-Pentyn-1-ol, 5-(trimethylsilyloxy)-; TMS-protected 3-Pentyn-1-ol; 5-(TMS-oxy)-3-pentyn-1-ol; 3-Pentyn-1-ol TMS ether; (3-Pentyn-1-yloxy)trimethylsilane; Trimethyl((pent-3-yn-1-yl)oxy)silane
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and process chemistry. Each batch is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity, purity, and consistency. Certificates of Analysis (COA) are available upon request, providing full transparency on all critical quality attributes. We are committed to supplying material that meets the stringent requirements of our global customer base in regulated and non-regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.