Description

Trimethylsilyl Isocyanate is a highly reactive organosilicon reagent primarily used as a silylating agent for the protection of alcohols and amines, and as a key building block in organic synthesis. Its value lies in its ability to introduce the trimethylsilyl (TMS) group under mild conditions, facilitating complex molecule construction in pharmaceutical and agrochemical research. This product is essential for R&D chemists and process development scientists in the fine chemical, pharmaceutical intermediate, and advanced material sectors.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for introducing the isocyanate and silyl functionalities in the production of active pharmaceutical ingredients (APIs) and advanced drug candidates.
• Peptide & Carbohydrate Chemistry: Used as a protecting agent for hydroxyl and amino groups during the synthesis of complex peptides, nucleotides, and sugar derivatives.
• Agrochemical Manufacturing: Employed in the synthesis of herbicides, fungicides, and insecticides where silylated intermediates are required for selective reactions.
• Polymer & Material Science: Serves as a monomer or modifier in the production of specialized polyurethanes, silicones, and other polymers with tailored properties.
• Analytical Derivatization: Utilized to derivative polar compounds (like alcohols and phenols) for Gas Chromatography (GC) and Mass Spectrometry (MS) analysis to improve volatility and detection.
• Cross-Coupling Reactions: Acts as a reagent in palladium-catalyzed and other metal-mediated cross-coupling reactions to construct carbon-heteroatom bonds.

Basic Information

Product Name	Trimethylsilyl Isocyanate
CAS No.	1118-02-1
Molecular Formula	C4H9NOSi
Molecular Weight	115.21 g/mol
Synonyms	Isocyanatotrimethylsilane; TMS-NCO; Trimethylsilicon isocyanate; (Isocyanato)trimethylsilane; Trimethylsilyl isocyanide (common misnomer); NSC 9375; Silane, isocyanatotrimethyl-; Trimethylsilyl ester of isocyanic acid
EINECS	214-264-9

Quality Control

Our Trimethylsilyl Isocyanate is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including GC and NMR, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C. Keep away from heat, sparks, open flames, and incompatible materials such as water, alcohols, amines, and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Density (at 20°C)	0.85 - 0.90 g/mL
Refractive Index (n20D)	1.390 - 1.400
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.